501357-89-7

Basic information

• Product Name: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine
• Synonyms: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine;8-Chloro[1,2,4]triazolo[4,3-a]pyridine 98%;8-chloro-[1, 2, 4] triazolopyridine;8-Chloro[1,2,4]triazolo[4,3-a]pyridine98%
• CAS NO: 501357-89-7
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.56906
• Product Categories: blocks;Pyridines;Heterocycle-Pyridine series
• Mol File: 501357-89-7.mol

Chemical Properties

• Melting Point: 184-186
• Appearance: /
• Density: 1.51 g/cm³
• Refractive Index: 1.712
• Storage Temp.: Keep Cold
• PKA: 2.02±0.50(Predicted)
• CAS DataBase Reference: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine(501357-89-7)
• EPA Substance Registry System: 8-Chloro[1,2,4]triazolo[4,3-a]pyridine(501357-89-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 501357-89-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Chloro[1,2,4]triazolo[4,3-a]pyridine is utilized as a key intermediate in the synthesis of biologically active molecules for drug discovery and development. Its unique structure and chemical properties make it a valuable building block in organic synthesis and medicinal chemistry.
Used in Drug Discovery and Development:
In the field of drug discovery and development, 8-Chloro[1,2,4]triazolo[4,3-a]pyridine is employed as a starting material for the design of novel drugs. It has potential applications in the treatment of various diseases, including cancer, inflammation, and neurological disorders, due to its biological activity and pharmacological properties.
Used in Medicinal Chemistry Research and Development:
8-Chloro[1,2,4]triazolo[4,3-a]pyridine is also a subject of interest for research and development in medicinal chemistry. Its unique structure and potential biological activity make it a promising candidate for further exploration and optimization to enhance its therapeutic potential and develop new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C6H4ClN3/c7-5-2-1-3-10-4-8-9-6(5)10/h1-4H

Upstream product

• 64-18-6 formic acid 
• 22841-92-5 (3-chloro-2-pyridyl)hydrazine 
• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 
• 50-00-0 formaldehyd 
• 2402-77-9 2,3-dichloro-pyridine 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Microwave assistant one pot synthesis, crystal structure, antifungal activities and 3D-QSAR of novel 1,2,4-triazolo[4,3-a]pyridines

A series of novel 1,2,4-triazolo[4,3-a]pyridines were synthesized, and their structures were characterized by 1H NMR, MS, elemental analysis, and single-crystal X-ray diffraction analysis. The antifungal activities were evaluated. The antifungal activity results indicated that the compound 2b, 2g, 2p, and 2i exhibited good activities. The activity of compound 2b, 2g, 2p, and 2i can compare with the commercial pesticide. The 3D-QSAR model was developed using CoMFA method. Both the steric and electronic field distributions of CoMFA are in good agreement in this work and will be very helpful in designing a new set of analogues. A series of novel 1,2,4-triazolo[4,3-a]pyridines were synthesized. The antifungal activity results indicated that the compounds 2b, 2g, 2p, and 2i exhibited good activities. The activity of compounds 2b, 2g, 2p, and 2i can compare with the commercial pesticide. The 3D-QSAR model was developed using CoMFA method.

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Copper(i)-catalyzed benzylation of triazolopyridine through direct C-H functionalization

A general and efficient copper-catalyzed benzylation reaction of triazolopyridine with N-tosylhydrazones was developed. This reaction forms a C(sp2)-C(sp3) bond through cross-coupling, and represents an exceedingly practical method t

PROCESS FOR PREPARING PYRIDYLPYRAZOLE COMPOUNDS AND DERIVATIVES THEREOF FROM PYRIDYLHYDRAZINE

The present invention relates to a process for preparing pyndylpyrazole compounds of the formula (I) starting from pyridylhydrazine of formula (II) The present invention relates also to processes comprising further preceding and/or subsequent reaction steps, leading to anthranilamide pesticides or to precursors for them.