501936-07-8

Basic information

• Product Name: 7-METHOXY-4,5-DIHYDRO-2H-BENZO[G]INDAZOLE
• Synonyms: 7-METHOXY-4,5-DIHYDRO-2H-BENZO[G]INDAZOLE;7-methoxy-2H,4H,5H-benzo[g]indazole
• CAS NO: 501936-07-8
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• Mol File: 501936-07-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-METHOXY-4,5-DIHYDRO-2H-BENZO[G]INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-4,5-DIHYDRO-2H-BENZO[G]INDAZOLE(501936-07-8)
• EPA Substance Registry System: 7-METHOXY-4,5-DIHYDRO-2H-BENZO[G]INDAZOLE(501936-07-8)

Safety Data

• Hazardous Substances Data: 501936-07-8(Hazardous Substances Data)

Upstream product

• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 68950-67-4 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Synthesis of aryl-substituted or aryl-fused N-hydroxyethyl and N-hydroxymethypyrazole derivatives as potential ligands for the estrogen receptor

A new series of N-hydroxyethylpyrazole (12a-f) and N-hydroxymethylpyrazole derivatives (15a-f) were designed for their estrogenic activities, having a 11.0 ± 0.5 A distance between their two hydroxyl groups, aliphatic-OH and phenolic-OH similar to 17β-estradiol (E2) as an endogenous hormone. To synthesize the title compounds, the key intermediate 1,3-dicarbonyl derivatives (2 and 8), were treated with hydrazine hydrate to produce the pyrazole ring 5 and 9. Further hydroxyalkylation of the latter produced the title pyrazoles. The position of hydroxyethyl or hydroxymethyl substituents in the products was determined through 2D NOE NMR spectroscopy.

Selective synthesis of some 4,5-dihydro-2H-benzo[g]indazoles and 8,9-dihydro-2H-benzo[e]indazoles via the Vilsmeier-Haack reaction under thermal and microwave assisted conditions

A selective and easy method is described for the synthesis of 4,5-dihydro-2H-benzo[g]indazoles and 8,9-dihydro-2H-benzo[e]indazoles by the Vilsmeier-Haack reaction of various tetralone phenylhydrazones under thermal and microwave irradiation conditions.