68950-67-4Relevant articles and documents
The Quinary Catalyst-Substrate Complex Induced Construction of Spiro-Bridged or Cagelike Polyheterocyclic Compounds via a Substrate-Controlled Cascade Process
Wang, Chen,Chen, Ying-Han,Wu, Hui-Chun,Wang, Cong,Liu, Yan-Kai
supporting information, p. 6750 - 6755 (2019/09/12)
The asymmetric organocatalytic cascade reaction of cyclic β-oxo aldehydes to 2-hydroxycinnamaldehydes is developed. The bifunctional tertiary amine-thiourea catalyst was used in a rationally designed multiple catalysis where the asymmetric iminium catalysis and thiourea anion-binding catalysis were combined by carboxylate anion as a ternary catalytic system to form a quinary catalyst-substrate complex, providing an efficient protocol for the construction of enantioenriched spiro-bridged or cagelike polyheterocyclic compounds. The reuse of catalysts was also successfully realized.
Synthesis and structure-activity relationships of 2-amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents
Reddy, Gadarla Randheer,Kuo, Ching-Chuan,Tan, Uan-Kang,Coumar, Mohane Selvaraj,Chang, Chi-Yen,Chiang, Yi-Kun,Lai, Mei-Jung,Yeh, Jiann-Yih,Wu, Su-Ying,Chang, Jang-Yang,Liou, Jing-Ping,Hsieh, Hsing-Pang
supporting information; experimental part, p. 8163 - 8167 (2009/12/07)
A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity. 2-Amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalene, 9 and 8, respectively, showed strong antiproliferative activity
PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS
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