68950-67-4

Usage

Uses

Used in Pharmaceutical Synthesis:
6-Methoxy-1-oxo-1,2,3,4-tetrahydro-[2]-naphthaldehyde is utilized as a key intermediate in the synthesis of a variety of pharmaceuticals. Its chemical properties make it suitable for the development of new drugs and organic products.
Used in Fragrance and Flavoring Production:
Leveraging its aromatic properties, 6-Methoxy-1-oxo-1,2,3,4-tetrahydro-[2]-naphthaldehyde is used as a component in the production of fragrances and flavorings, adding unique scents and tastes to various consumer products.
Used in Chemical Research and Development:
6-METHOXY-1-OXO-1,2,3,4-TETRAHYDRO-[2]-NAPHTHALDEHYDE is also employed in research and development for new chemical compounds, particularly in the field of organic chemistry. Its unique properties make it a valuable asset for scientific exploration and innovation.
Used in Organic Chemistry:
6-Methoxy-1-oxo-1,2,3,4-tetrahydro-[2]-naphthaldehyde holds potential applications in the broader field of organic chemistry, where its reactivity and structural features can be harnessed for the creation of novel chemical entities and materials.

Upstream product

• 109-94-4 formic acid ethyl ester 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 122-51-0 orthoformic acid triethyl ester 
• 107-31-3 Methyl formate 

Downstream Products

• 501936-07-8 7-methoxy-4,5-dihydro-2H-benzo[g]indazole 
• 31184-53-9 4,5-dihydro-2H-benzo[g]indazol-7-ol 

Relevant academic research and scientific papers

The Quinary Catalyst-Substrate Complex Induced Construction of Spiro-Bridged or Cagelike Polyheterocyclic Compounds via a Substrate-Controlled Cascade Process

The asymmetric organocatalytic cascade reaction of cyclic β-oxo aldehydes to 2-hydroxycinnamaldehydes is developed. The bifunctional tertiary amine-thiourea catalyst was used in a rationally designed multiple catalysis where the asymmetric iminium catalysis and thiourea anion-binding catalysis were combined by carboxylate anion as a ternary catalytic system to form a quinary catalyst-substrate complex, providing an efficient protocol for the construction of enantioenriched spiro-bridged or cagelike polyheterocyclic compounds. The reuse of catalysts was also successfully realized.

Synthesis of aryl-substituted or aryl-fused N-hydroxyethyl and N-hydroxymethypyrazole derivatives as potential ligands for the estrogen receptor

A new series of N-hydroxyethylpyrazole (12a-f) and N-hydroxymethylpyrazole derivatives (15a-f) were designed for their estrogenic activities, having a 11.0 ± 0.5 A distance between their two hydroxyl groups, aliphatic-OH and phenolic-OH similar to 17β-estradiol (E2) as an endogenous hormone. To synthesize the title compounds, the key intermediate 1,3-dicarbonyl derivatives (2 and 8), were treated with hydrazine hydrate to produce the pyrazole ring 5 and 9. Further hydroxyalkylation of the latter produced the title pyrazoles. The position of hydroxyethyl or hydroxymethyl substituents in the products was determined through 2D NOE NMR spectroscopy.

Synthesis and structure-activity relationships of 2-amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents

A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity. 2-Amino-1- aroylnaphthalene and 2-hydroxy-1-aroylnaphthalene, 9 and 8, respectively, showed strong antiproliferative activity

Lewis base-catalyzed [2,3]-Wittig rearrangement of silyl enolates generated from α-allyloxy carbonyl compounds

Lewis base-catalyzed [2,3]-Wittig rearrangement of silyl enolates generated from α-allyloxy carbonyl compounds is described. The [2,3]-Wittig rearrangement of silyl enolates generated from α-allyloxy ketones proceeded smoothly by using a Lewis base cataly

PYRIMIDINE DERIVATIVES

The disclosed pyrimidine derivatives, and pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, in particular use as 5HT 2C-antagonists. The invention is also directed to formulations and methods for treatment.