cas 5021-50-1, thiazolo[5,4-d]pyrimidin-7-ol | Articles data ｜lookchem

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5021-50-1

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Phosphorus Pentoxide in Organic Synthesis. XXXV. Synthesis of Thiazolopyrimidin-7-amines and Purine-6-thiones from 5-Acylamino-4-thiazolecarboxamides
5-Acylamino-4-thiazolecarboxamides (1) have been converted into a series of N-aryl-7-thiazolopyrimidinamines (3) and 9-aryl-1,9-dihydro-6H-purine-6-thiones (4) by heating in a mixture of phosphorus pentoxide, triethylamine hydrochloride and an anil
Andersen, Knud Erik,Hammad, Mahmoud,Hilmy, Khalid M. H.,Pedersen, Erik B.
p. 708 - 711
(2007/10/02)

Azole series. I. Reaction of 2-(acylamino)thioacetamides, leading to 5-aminothiazoles and to thiazolo[5,4-d]pyrimidines.
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Sekiya,Osaki
p. 1319 - 1325
(2007/10/07)

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Chemical Properties

Melting Point: >300 °C
Boiling Point: 350.806°C at 760 mmHg
Flash Point:165.962°C
Density: 1.681g/cm³
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.791
PKA: 9.74±0.20(Predicted)
PSA: 86.88000
LogP: 0.37960

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