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2,4-Diphenyl-1,3-thiazole-5-carboxylic acid is an organic compound characterized by its thiazole and carboxylic acid functional groups. It is a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of cancer and other diseases.

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  • 502935-47-9 Structure
  • Basic information

    1. Product Name: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
    2. Synonyms: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID;2,4-DIPHENYLTHIAZOLE-5-CARBOXYLIC ACID;2,4-Diphenyl-1,3-thiazole-5-carboxylic acid 97%;2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC
    3. CAS NO:502935-47-9
    4. Molecular Formula: C16H11NO2S
    5. Molecular Weight: 281.33
    6. EINECS: N/A
    7. Product Categories: pharmacetical
    8. Mol File: 502935-47-9.mol
  • Chemical Properties

    1. Melting Point: 212 °C
    2. Boiling Point: 484.1 °C at 760 mmHg
    3. Flash Point: 246.6 °C
    4. Appearance: /
    5. Density: 1.307 g/cm3
    6. Vapor Pressure: 3.49E-10mmHg at 25°C
    7. Refractive Index: 1.653
    8. Storage Temp.: Refrigerator, Under inert atmosphere
    9. Solubility: DMSO (Slightly, Sonicated), Methanol (Very Slightly, Heated, Sonicated)
    10. CAS DataBase Reference: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(502935-47-9)
    12. EPA Substance Registry System: 2,4-DIPHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(502935-47-9)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 502935-47-9(Hazardous Substances Data)

502935-47-9 Usage

Uses

Used in Pharmaceutical Industry:
2,4-Diphenyl-1,3-thiazole-5-carboxylic acid is used as a key intermediate in the synthesis of FASN (Fatty Acid Synthase) inhibitors for the treatment of cancer and other diseases. These inhibitors target the enzyme responsible for the synthesis of fatty acids, which is often overexpressed in cancer cells, leading to uncontrolled cell growth and proliferation. By inhibiting FASN, these compounds can potentially slow down or stop the growth of cancer cells, making them a valuable tool in the development of novel cancer therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 502935-47-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,2,9,3 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 502935-47:
(8*5)+(7*0)+(6*2)+(5*9)+(4*3)+(3*5)+(2*4)+(1*7)=139
139 % 10 = 9
So 502935-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H11NO2S/c18-16(19)14-13(11-7-3-1-4-8-11)17-15(20-14)12-9-5-2-6-10-12/h1-10H,(H,18,19)

502935-47-9Relevant articles and documents

Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004

Raeppel, Franck,Raeppel, Stéphane L.,Therrien, Eric

, p. 3810 - 3815 (2015/08/24)

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS

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Paragraph 0073; 0074, (2014/09/30)

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

A general and efficient PIFA mediated synthesis of heterocycle-fused quinolinone derivatives

Herrero, M.Teresa,Tellitu, Imanol,Domínguez, Esther,Hernández, Susana,Moreno, Isabel,SanMartín, Raúl

, p. 8581 - 8589 (2007/10/03)

A new application of the hypervalent iodine reagent phenyliodine(III)bis(trifluoroacetate) (PIFA) has been developed for the construction of a series of N, O, S-containing heterocycle-fused quinolinone derivatives in a general and efficient way. An altern

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