503058-51-3

Basic information

• Product Name: 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl
• Synonyms: 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl;4-Chloro-3-methoxypicolinyl chloride hydrochloride;KPQDKAMSAVONFC-UHFFFAOYSA-N
• CAS NO: 503058-51-3
• Molecular Formula: C7H8Cl3NO
• Molecular Weight: 228.50352
• Mol File: 503058-51-3.mol

Chemical Properties

• Boiling Point: 286.3 °C at 760 mmHg
• Flash Point: 126.9 °C
• Appearance: /
• CAS DataBase Reference: 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl(503058-51-3)
• EPA Substance Registry System: 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl(503058-51-3)

Safety Data

• Hazardous Substances Data: 503058-51-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl is used as a reactant for the preparation of symmetric bis-benzimidazole derivatives, which are known for their ability to inhibit gastric acid secretion. This application is particularly relevant in the development of medications for treating conditions related to excessive stomach acid, such as gastroesophageal reflux disease (GERD) and peptic ulcers.
4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl's unique structure allows it to be a versatile building block in the synthesis of various pharmaceutical agents, potentially leading to the discovery of new drugs with improved efficacy and reduced side effects. Its use in the pharmaceutical industry highlights the importance of organic chemistry in drug discovery and development.

Upstream product

• 170621-85-9 4-Chloro-2-hydroxymethyl-3-methoxypyridine 

Downstream Products

• 368890-20-4 (5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole 

Relevant articles and documents

ISOTOPICALLY SUBSTITUTED PROTON PUMP INHIBITORS

The invention relates to benzimidazoles of Formula (1) and to pharmaceutical compositions comprising these compounds, further to intermediates of Formula (2 and 3).

ISOTOPICALLY SUBSTITUTED PANTOPRAZOLE

The invention relates to compounds of formula 1 and to medicaments comprising these compounds, further to intermediates of formula 2 and 3.

Benzimidazole derivatives

A benzimidazole derivative of formula (1): (wherein R represents a hydrogen atom or a methoxy group, and n is 0 or 1) or a salt thereof; and a medicament containing the same. The compounds of the present invention, due to minimized difference in therapeutic effect between subjects, which difference would otherwise be derived from different CYP2C19 activity from subject to subject, ensure that all patients can enjoy proper therapeutic effects at the same dose of the drug. Also, the compounds of the invention have low risk of drug interaction caused by induction of CYP1A family member enzymes, as well as low risk of development of cancer, and thus is useful as a remedy for peptic ulcer, reliably providing therapeutic effects with safety.