4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl

Base Information

• Chemical Name: 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl
• CAS No.: 503058-51-3
• Molecular Formula: C7H8Cl3NO
• Molecular Weight: 228.5035
• Hs Code.: 2933399090
• Mol file: 503058-51-3.mol

Synonyms:4-chloro-2-chloromethyl-3-methoxypyridine chloride;4-chloro-2-chloromethyl-3-methoxypyridinium chloride;4-Chloro-2-chloromethyl-3-methoxypyridine hydrochloride;OR9946;

Chemical Property of 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl

Chemical Property:

• Boiling Point: 286.3 °C at 760 mmHg
• Flash Point: 126.9 °C
• PSA: 22.12000
• LogP: 3.28440

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-chloromethyl-3-methoxypyridineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Chloro-2-chloromethyl-3-methoxypyridine Hydrochloride is a useful reactant in preparation of symmetric bis0benzimidazole derivatives for inhibition of gastric acid secretion.

Technology Process of 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl

There total 1 articles about 4-Chloro-2-chloroMethyl-3-Methoxypyridine, HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Chloro-2-hydroxymethyl-3-methoxypyridine (170621-85-9) → 4-chloro-2-chloromethyl-3-methoxypyridine hydrochloride (503058-51-3)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.666667h;

Reference yield: 92.0%

5-trideuteriomethoxy-1H-benzimidazole-2-thiol (922730-86-7) + 4-chloro-2-chloromethyl-3-methoxypyridine hydrochloride (503058-51-3) → (5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole (368890-20-4)

Guidance literature:

With sodium hydroxide; In water; toluene; at 55 - 65 ℃; for 4 - 6h;

Reference yield: 92.0%

4-chloro-2-chloromethyl-3-methoxypyridine hydrochloride (503058-51-3) + 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (97963-62-7) → (5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole (368890-20-4)

Guidance literature:

With sodium hydroxide; In water; toluene; at 55 - 65 ℃; for 4 - 6h;

upstream raw materials:

4-Chloro-2-hydroxymethyl-3-methoxypyridine

Downstream raw materials:

(5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole