503617-68-3Relevant articles and documents
Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists
Kulkarni, Santosh S.,Newman, Amy Hauck
, p. 2074 - 2079 (2007/10/03)
A series of heterobiaryl amides was designed and synthesized as novel mGluR5 antagonists. The synthesis using palladium catalyzed Suzuki-Miyaura cross-coupling reactions provided an array of compounds with a range of in vitro activities. In particular, compound 9e, 4(3,5-difluorophenyl)-N-(6-methylpyridin-1-yl)picolinamide, exhibited nanomolar affinity at the mGluR5 and will serve as a template for future drug design.
Synthesis and antioxidant properties of novel N-substituted indole-2-carboxamide and indole-3-acetamide derivatives
Oelgen, Suereyya,Coban, Tuelay
, p. 331 - 338 (2007/10/03)
A series of N-substituted indole-2-carboxamide and indole-3-acetamide derivatives have been prepared and their in vitro effects on rat liver lipid peroxidation levels and superoxide anion formation were determined. The results clearly demonstrate that indole derivatives 4, 5, 10, 15, 17 are very efficient antioxidants compared to α-toco-pherol.
