503828-19-1Relevant articles and documents
PHARMACEUTICAL PREPARATIONS COMPRISING INSULIN, ZINC IONS AND A ZINC-BINDING LIGAND
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Page/Page column 268, (2008/06/13)
Novel preparations comprising branched ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The preparations have a prolonged action designed for flexible injection regimes.
PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN
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Page/Page column 263, (2010/02/15)
Novel preparations comprising ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer wherein the ligand is extended by protamine that are capable of prolonging the ac-tion of insulin preparations.
Stabilised insulin compositions
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Page/Page column 143, (2008/06/13)
The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The resulting preparations have improved physical and chemical stability.
PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN
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Page/Page column 264-265, (2010/02/08)
Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.
Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer
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Page 94, (2010/11/30)
Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.