50402-56-7

Basic information

• Product Name: 1,5-EDANS
• Synonyms: N-(AMINOETHYL)-5-NAPHTHYLAMINE-1-SULFONIC ACID;N-(2-AMINOETHYL)-5-NAPHTHYLAMINE-1-SULPHONIC ACID;EDANS;EDANS ACID;1,5-EDANS;5-(2-AMINOETHYLAMINO)-1-NAPHTHALENE SULFONIC ACID;5-((2-AMINOETHYL)AMINO)NAPHTHALENE-1-SULFONIC ACID;5-(2-aminoethylamino)-1-naphthalene-*sulfonic aci
• CAS NO: 50402-56-7
• Molecular Formula: C₁₂H₁₄N₂O₃S
• Molecular Weight: 266.32
• EINECS: 256-575-5
• Product Categories: Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;MTS & Sulfhydryl Active Reagents;Amines;Aromatics;Sulfur & Selenium Compounds;Fluorescent Dyes
• Mol File: 50402-56-7.mol

Chemical Properties

• Melting Point: >350°C
• Appearance: /
• Density: 1.432 g/cm³
• Refractive Index: 1.691
• Storage Temp.: Refrigerator
• Solubility: Aqueous Base (Slightly), DMSO (Slightly, Heated)
• PKA: -0.37±0.40(Predicted)
• CAS DataBase Reference: 1,5-EDANS(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-EDANS(50402-56-7)
• EPA Substance Registry System: 1,5-EDANS(50402-56-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-27-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 50402-56-7(Hazardous Substances Data)

Usage

Uses

Used in Analytical Chemistry:
1,5-EDANS is used as a fluorescent derivatization reagent for the detection and analysis of various compounds in analytical chemistry. Its application reason is due to its unique spectral properties, which allow for sensitive and selective detection of target molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1,5-EDANS is used as a fluorescent probe for studying the interactions between drugs and their target biomolecules. The application reason is its ability to provide valuable information on binding affinities, kinetics, and structural changes upon interaction.
Used in Environmental Monitoring:
1,5-EDANS is employed as a fluorescent tracer in environmental monitoring to detect and quantify pollutants and contaminants in water and soil samples. The application reason is its high sensitivity and specificity, which enable accurate detection of trace amounts of target analytes.
Used in Material Science:
In material science, 1,5-EDANS is used as a fluorescent label for the characterization of materials at the molecular level. The application reason is its ability to provide insights into the structure, dynamics, and interactions of materials, which is crucial for the development of new materials with desired properties.

InChI:InChI=1/C12H14N2O3S/c13-7-8-14-11-5-1-4-10-9(11)3-2-6-12(10)18(15,16)17/h1-6,14H,7-8,13H2,(H,15,16,17)

Upstream product

• 5419-77-2 6-Hydroxy-2-naphthalene sulfonic acid sodium salt 
• 107-15-3 ethylenediamine 
• 1558-23-2 3,6-dimethyl-1,2,4,5-tetrazine 
• 1606181-57-0 2-(6-methyl-1,2,4,5-tetrazin-3-yl)acetic acid 

Downstream Products

• 143774-97-4 Boc-Glu(EDANS)-OBzl 
• 816430-11-2 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid 
• 1375413-65-2 5-((2-(4-azidobenzamido)ethyl)amino)naphthalene-1-sulfonic acid 

Relevant articles and documents

Redox-based selective fluorometric detection of homocysteine

Plasma homocysteine (Hcy) is an important risk factor for various diseases. A novel redox-sensitive fluorescent probe is developed for the selective detection of Hcy. A linear calibration curve has been obtained in buffer and plasma for the quantitative determination of Hcy in such media. This journal is

Chemically modified dansyl probes: A fluorescent diagnostic for ion and proton detection in solution and in polymers

The fluorescence emission intensity of the dansyl group is significantly diminished upon appending an ethyldimethylamino group to the N1 nitrogen substituent. Addition of acids and metal ions (i.e., Zn2+) to solutions of trimethylethylenediamine naphthalene sulfonamide (trinsyl) 2 produces a >25-fold increase in fluorescence intensity. Trinsyl probe 2 has been used as a diagnostic for the diffusion of protons and metal ions in a network polymer as well as an optical reporter for the glass transition temperature.

Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics

The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans-cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylamine substrates has so far proven difficult. Here, we report a fluorogenic tool consisting of a TCO-linked EDANS fluorophore and a DABCYL quencher for accurate determination of both the click and release rate constants for any tetrazine at physiologically relevant concentrations.

HSV-2 type-specific immunoassays using glycoprotein G2 peptides

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