- Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2)
-
(NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism. Thus, there is a need to develop inhibitors of NQO2 that are active in v
- Hussein, Buthaina,Ikhmais, Balqis,Kadirvel, Manikandan,Magwaza, Rachael N.,Halbert, Gavin,Bryce, Richard A.,Stratford, Ian J.,Freeman, Sally
-
-
- Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives
-
The present report describes the synthesis and cell growth inhibition of certain 4-anilino-2-phenylquinoline derivatives. 4-(4-Acetylphenylamino)-6- methoxy-2-phenylquinoline (11), its oxime 15a, and its methyloxime 15b, exhibited significant cytotoxicity
- Zhao, Yue-Ling,Chen, Yeh-Long,Chang, Feng-Shuo,Tzeng, Cherng-Chyi
-
p. 792 - 797
(2007/10/03)
-
- Quinoline derivatives as antitubercular/antibacterial agents
-
A number of quinoline derivatives of known antibacterial agents have been prepared and tested against the micro-organisms S. coli, S. paratyphi B, S. aureus and in particular against Mycobacterium tuberculosis H37-Rv. It has not been possibfe to establish correlation between antibacterial and antitubercular activities of these compounds. However, the antitubercular effect at MIC of 5 μg/mL against H37Rv shows that many modified compounds are more inhibitory than the parent agents such as 3-aminophenol, sulphamethoxazole, sulphaphenazole, sulphathiazole and monoacetyldapsone; among these the most effective are those with substituents such as 6-methyl, 6-chloro, 6-ethoxy-, or 8-methoxy functions in quinoline moiety.
- Desai,Desai, Pratibha,Machhi, Dilip,Desai,Patel, Dinesh
-
p. 871 - 873
(2007/10/03)
-