50593-72-1Relevant articles and documents
Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2)
Hussein, Buthaina,Ikhmais, Balqis,Kadirvel, Manikandan,Magwaza, Rachael N.,Halbert, Gavin,Bryce, Richard A.,Stratford, Ian J.,Freeman, Sally
, (2019/09/10)
(NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism. Thus, there is a need to develop inhibitors of NQO2 that are active in v
Quinoline derivatives as antitubercular/antibacterial agents
Desai,Desai, Pratibha,Machhi, Dilip,Desai,Patel, Dinesh
, p. 871 - 873 (2007/10/03)
A number of quinoline derivatives of known antibacterial agents have been prepared and tested against the micro-organisms S. coli, S. paratyphi B, S. aureus and in particular against Mycobacterium tuberculosis H37-Rv. It has not been possibfe to establish correlation between antibacterial and antitubercular activities of these compounds. However, the antitubercular effect at MIC of 5 μg/mL against H37Rv shows that many modified compounds are more inhibitory than the parent agents such as 3-aminophenol, sulphamethoxazole, sulphaphenazole, sulphathiazole and monoacetyldapsone; among these the most effective are those with substituents such as 6-methyl, 6-chloro, 6-ethoxy-, or 8-methoxy functions in quinoline moiety.
