- An Efficient Direct α-Alkylation of Ketones with Primary Alcohols Catalyzed by [Ir(cod)CI]2/PPh3/KOH System without Solvent
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α-Alkylation of ketones was successfully achieved by the reaction of ketones with alcohols catalyzed by iridium complexes in the presence of a small amount of base. For example, 2-octanone was allowed to react with butanol under the influence of [Ir(cod)Cl]2/PPh3/KOH to give 6-dodecanone in good yield. The reaction was found to proceed by using a 1:1 mixture of ketone and alcohol without use of any solvent. Copyright
- Taguchi, Kazuhiko,Nakagawa, Hideto,Hirabayashi, Tomotaka,Sakaguchi, Satoshi,Ishii, Yasutaka
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- Efficient Conjugate Alkylation of α,β-Unsaturated Nitro Olefins by Triorganoalanes
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Both trialkylaluminum (AlR3; R = Et, i-Bu) and triorganoaluminum etherates (AlR3*OEt2; R = Et, i-Bu, Ph) rapidly react with α,β-unsaturated nitro olefins to give only 1,4-monoalkylated products in high yields.The natures of substrates, the reaction conditions as well as the reagents molar ratio, do not cause significant variations on the recovered products.
- Pecunioso, Angelo,Menicagli, Rita
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