- N,N′-Dihydroxy-N,N′-diisopropylhexanediamide, a siderophore analogue, as a possible iron chelating agent for hydroponic conditions: metal equilibrium studies
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Synthetic iron chelates are the most efficient iron fertilizers. The stability in solution of the iron chelates in the presence of other metal cations that may compete with iron for the chelating agent in nutrient solutions is crucial for its effectiveness in supplying iron to plants. In this work, the chelating properties of N,N-dihydroxy-N,N′-diisopropylhexanediamide (DPH), a biological model of the natural siderophore rhodotorulic acid, were evaluated in order to assess its potentialities for being used, as an iron chelate, in hydroponic cultures. For this purpose, the complexation for the metals [Ca(II), Cu(II), Mg(II), Mn(II) or Zn(II)]–DPH–OH systems has been studied using pH potentiometry and the overall stability constants have been determined for the first time. For all M–DPH–OH systems, MHL and ML species were identified. For [Cu(II), Mn(II) or Zn(II)]–DPH–OH systems, the M2L3 species was detected, whereas formation of ML(OH) species was found in the [Ca(II) or Mg(II)]–DPH–OH systems. Finally, the chemical stability of iron chelated with DPH in hydroponic conditions was assessed by computer chemical simulations and compared with the one predicted when iron is chelated with ethylenediamine-N,N′-bis(o-hydroxyphenyl)acetic acid (o,o-EDDHA) in similar conditions.
- Martins, Jo?o G.,Ferreira, Carlos M. H.,Dey, Suvendu S.,Barros, Maria Teresa,Soares, Helena M. V. M.
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- Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes
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Six new N [(4-aminophenyl)sulfonyl]acetamide based hydroxytriazenes have been synthesized and characterized using elemental analysis, IR, 1H NMR, 13C NMR and MASS spectral analysis. Further, their theoretical predictions for probable activities have been taken using PASS (Prediction of Activity Spectra for Substance). Although a number of activities have been predicted but specifically anti-inflammatory, antiradical, anti-diabetic activities have been experimentally validated which proves that theoretical predictions agree with the experimental results. The object of the Letter is to establish Computer Aided Drug Design (CADD) using our compounds.
- Agarwal, Shilpa,Baroliya, Prabhat K.,Bhargava, Amit,Tripathi,Goswami
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- LOW TOXICITY NMP SUBSTITUTES AND USES THEREOF
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The present technology is directed to compounds Formulas I, II, III, and IV as well as compositions that include one or more of the compounds and methods of making the compounds. In particular, the present compounds may be used as a replacement for NMP in compositions to produce lower toxicity compositions.
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Paragraph 0154
(2021/08/20)
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- Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies
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Herein, we report synthesis, characterization, anti-diabetic, anti-inflammatory and anti-oxidant activities of hydroxytriazenes derived from sulpha drugs, namely sulphanilamide, sulphadiazine, sulphapyridine and sulphamethazine. Before biological screening of the compounds, theoretical prediction using PASS was done which indicates probable activities ranging from Pa (probable activity) values 65–98% for anti-inflammatory activity. As per the predication, experimental validation of some of the predicted activities particularly anti-diabetic, anti-inflammatory and anti-oxidant was done. Anti-diabetic activities have been screened using two methods namely α-amylase and α-glucosidase inhibition method and IC50 values were ranging from 66 to 260 and 148 to 401 μg/mL, while for standard drug acarbose the values were 12 μg/mL and 70 μg/mL, respectively. Docking studies have also been done for antidiabetic target pancreatic alpha amylase. The molecular docking studies in α-amylase enzyme reveal that the middle phenyl ring of all the compounds mainly occupies in the small hydrophobic pocket formed by the Ala198, Trp58, Leu162, Leu165 and Ile235 residues and sulphonamide moiety establish H-bond interaction by two water molecules. Further, anti-inflammatory activity has been evaluated using carrageenan induced paw-edema method and results indicate excellent anti-inflammatory activity by hydroxytriazenes (71 to 97%) and standard drug diclofenac 94% after 4 h of treatment. Moreover, antioxidant effect of the compounds was tested using DPPH and ABTS methods. All the compounds displayed good results (24–488 μg/mL) against ABTS radical and many compounds are more active than ascorbic acid (69 μg/mL) while all other compounds showed moderate activity against DPPH radical (292–774 μg/mL) and ascorbic acid (29 μg/mL). Thus, the studies reveal potential of sulfa drug based hydroxytriazenes as candidates for antidiabetic, anti-inflammatory and antioxidant activities which have been experimentally validated.
- Baroliya, Prabhat K.,Chauhan, R. S.,Dayma, Varsha,Dwivedi, Aparna,Goswami, A. K.,Sharma, Poonam,Tripathi, I. P.,Vanangamudi, Murugesan
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- A Process for the Preparation of Isopropylhydroxylamine
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Relates to manufacturing method of the present invention refers to IPHA (Isopropylhydroxylamine), specific under the presence of a catalyst at a temperature of 50 to 200 °C 2-nitro at a pressure of 50 to 200psi with rope in petal and then hydrogenated in the hydrogenation and which may progress towards.. Said method to improve (selectivity) and selectivity obtained rate (yield) are provided to form a film with glycol by reacting relates to characterized by manufacturing method.
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Paragraph 0044-
(2017/01/02)
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- Method for manufacturing ammonia-N
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PROBLEM TO BE SOLVED: To provide a method for producing an N-alkyl hydroxylamine, which produces a pure N-alkyl hydroxylamine in a high yield under a mild condition by a simple method, does not require a strict time management and is advantageous for industrial-scale production. SOLUTION: The method for producing an N-alkyl hydroxylamine includes bringing an N-alkyl nitro compound into contact with a hydrogen source in the presence of a solid catalyst supporting palladium on silica and in the absence of a significant quantity of a fourth reaction component. The method for producing an N-alkyl hydroxylamine includes bringing (A) an N-alkyl nitro compound into contact only with (B) a hydrogen source and (C) a solid catalyst supporting palladium on silica, or bringing (A) an N-alkyl nitro compound into contact only with (B) a hydrogen source, (C) a solid catalyst supporting palladium on silica and (D) a solvent that does not deactivate catalytic activity and has a pKa of ≥12. COPYRIGHT: (C)2012,JPOandINPIT
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Paragraph 0075-0076; 0083-0084
(2018/12/01)
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- Facile reduction of nitroarenes into anilines and nitroalkanes into hydroxylamines via the rapid activation of ammonia· borane complex by supported gold nanoparticles
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Gold nanoparticles supported on titania catalyse, even at a ppm loading level, the quantitative reduction of nitroarenes into anilines and nitroalkanes into alkylhydroxylamines by the ammonia× borane complex. No dehalohalogenation was seen in the case of chloro- or bromonitroarenes, while ester, cyano, or carboxylic acid functionalities also remain intact. The nitroarene to aniline reduction pathway does not require nitrosoarenes as intermediate products. Copyright
- Vasilikogiannaki, Eleni,Gryparis, Charis,Kotzabasaki, Vasiliki,Lykakis, Ioannis N.,Stratakis, Manolis
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supporting information
p. 907 - 911
(2013/05/08)
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- Highly enantioselective intermolecular hydroamination of allylic amines with chiral aldehydes as tethering catalysts
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Chirally LinkedIn: Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal diamine motifs in good yields and excellent enantioselectivities (see scheme). This work highlights simple chiral α-oxygenated aldehydes as effective organocatalysts capable of efficiently inducing asymmetry through transient intramolecularity. Copyright
- MacDonald, Melissa J.,Hesp, Colin R.,Schipper, Derek J.,Pesant, Marc,Beauchemin, André M.
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supporting information
p. 2597 - 2601
(2013/03/14)
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- Selective synthesis of N-Alkyl hydroxylamines by hydrogenation of nitroalkanes using supported palladium catalysts
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The selective hydrogenation of nitroalkanes to the corresponding N-alkyl hydroxylamines is achieved at room temperature with excellent yields (up to 98 %), by using common supported palladium catalysts. The reaction temperature is key to the highly selective formation of the hydroxylamines, which proceeds smoothly in a H2 atmosphere without additives. The catalyst can be recycled up to five times.
- Takenaka, Yasumasa,Kiyosu, Takahiro,Choi, Jun-Chul,Sakakura, Toshiyasu,Yasuda, Hiroyuki
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experimental part
p. 1166 - 1168
(2011/12/02)
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- Primary N-hydroxylamines
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The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
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- 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
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Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: where R1-R4are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
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Page column 17
(2008/06/13)
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- Primary N-hydroxylamines
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The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
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- Furan nitrone compounds
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Disclosed are furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compounds are useful as analytical reagents for detecting free radicals and as therapeutics for treating a wide variety of medical dysfunctions and diseases.
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- Furan nitrone compounds
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Disclosed are furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compounds are useful as analytical reagents for detecting free radicals and as therapeutics for treating a wide variety of medical dysfunctions and diseases.
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- AN EFFICIENT SYNTHESIS OF N-MONOALKYLATED HYDROXYLAMINES
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A general method for the preparation of N-alkylated hydroxylamines from alkyl halides is reported.
- Doleschall, Gabor
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p. 2993 - 2994
(2007/10/02)
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- NITROSOALKANE COMPLEXES OF IRON-PORPHYRINS: ANALOGY BETWEEN THE BONDING PROPERTIES OF NITROSOALKANES AND DIOXYGEN.
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The present paper describes different preparations of iron-porphyrin-nitrosoalka complexes and their study by various spectroscopic methods including an X-ray analysis. This study definitely proves the existence of the Fe**I**I-RNO bond, establishes the end-on N-binding mode of nitrosoalkanes in these ferroporphyrin complexes and gives information on the electronic structure of the Fe-RNO bond. Moreover, it points out a striking similarity between the bonding properties of nitrosoalkanes and dioxygen as ligands of iron(II)-porphyrins. Refs.
- Mansuy,Battioni,Chottard,Riche,Chiaroni
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p. 455 - 463
(2007/10/02)
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