51062-28-3

Basic information

• Product Name: dobutamine hydrochloride
• Synonyms: 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride, (R)-
• CAS NO: 51062-28-3
• Molecular Formula: C₁₈H₂₃NO₃*ClH
• Molecular Weight: 0
• Mol File: 51062-28-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: dobutamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: dobutamine hydrochloride(51062-28-3)
• EPA Substance Registry System: dobutamine hydrochloride(51062-28-3)

Safety Data

• Hazardous Substances Data: 51062-28-3(Hazardous Substances Data)

Upstream product

• 51062-27-2 (+)-(R)-3,4-dimethoxy-N-[3-(4-methoxyphenyl)-1-methyl-n-propyl]-2-phenylethylamine hydrochloride 
• 7440-44-0 pyrographite 
• 51062-14-7 N-[1-methyl-3-(4-methoxyphenyl)propyl]-2-(3,4-dimethoxyphenyl)ethylamine hydrochloride 

Relevant articles and documents

Synthetic method of dobutamine hydrochloride

The invention belongs to the field of bulk drug synthesis, and especially relates to a synthetic method of dobutamine hydrochloride. The synthetic method of dobutamine hydrochloride comprises following steps: anisyl acetone, an acid or acid hydrogenation donor, a catalyst, and 3, 4-dimethoxyphenethylamine are added into an organic solvent for mixing, reaction is carried out for 1 to 5h at 30 to 40DEG C; an obtained product is cooled to 10 to 30 DEG C through natural cooling, and filtering is carried out; the pH value of an obtained filtrate is adjusted with a 2% sodium hydroxide aqueous solution to 7 to 8, liquid separating and water washing are carried out; an obtained organic phase is added into concentrated hydrochloric acid for stirring salt forming, the organic phase is collected, and is distilled; an obtained concentrate is subjected to recrystallization in an organic solvent, and vacuum drying is carried out so as to obtain an intermediate; the intermediate is subjected to demethylating at 10 to 20 DEG C under the effect of Lewis acid, and salt forming in concentrated hydrochloric acid is carried out so as to obtain high purity dobutamine hydrochloride. The synthetic methodis capable of avoiding defects in the prior art, a novel dobutamine hydrochloride preparation method is provided, operation is simple, synthesis route is short, the synthetic method is friendly to the environment, yield is high, and cost is low.

4-(4-alkoxyphenyl)-2-butylamine derivative and process therefor

This invention relates to an optically active (+)-secondary amine of the formula: STR1 wherein R1 is a lower alkyl, and to a process for preparing a useful intermediate for the production of the optically active dopamine derivatives, namely, optically active (+)-primary amine of the formula: STR2 wherein R1 is a lower alkyl, characterized by the reduction of said optically active (+)-secondary amine.

Method for increasing cardiac contractility

N-Mono or dihydroxyphenylalkyl dopamine derivatives and salts thereof are inotropic agents useful in a method for treatment of acutely depressed cardiac insufficiency.