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FAM alkyne, 5-isomer is a high purity (95%) fluorescent probe with significant aqueous solubility. Its alkyne functionality allows for copper-catalyzed Click chemistry, making it a versatile tool for various applications.

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  • 510758-19-7 Structure
  • Basic information

    1. Product Name: FAM alkyne, 5-isomer
    2. Synonyms: FAM alkyne, 5-isomer
    3. CAS NO:510758-19-7
    4. Molecular Formula: C24H15NO6
    5. Molecular Weight: 413.379
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 510758-19-7.mol
  • Chemical Properties

    1. Melting Point: 313 °C(dec.)
    2. Boiling Point: 709.6±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.58±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Store in freezer, under -20°C
    8. Solubility: Soluble in DMSO, DMF, DCM
    9. PKA: 9.32±0.20(Predicted)
    10. CAS DataBase Reference: FAM alkyne, 5-isomer(CAS DataBase Reference)
    11. NIST Chemistry Reference: FAM alkyne, 5-isomer(510758-19-7)
    12. EPA Substance Registry System: FAM alkyne, 5-isomer(510758-19-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 510758-19-7(Hazardous Substances Data)

510758-19-7 Usage

Uses

Used in Bioconjugation:
FAM alkyne, 5-isomer is used as a bioconjugation agent for attaching biomolecules such as proteins, peptides, and oligonucleotides to other molecules or surfaces. The copper-catalyzed Click chemistry enables efficient and site-specific conjugation, improving the stability and functionality of the resulting bioconjugates.
Used in Cellular Imaging:
FAM alkyne, 5-isomer is used as a fluorescent probe for cellular imaging applications. Its high aqueous solubility and bright fluorescence allow for the visualization of cellular structures, dynamics, and interactions with high sensitivity and specificity.
Used in Drug Discovery:
FAM alkyne, 5-isomer is used as a tool in drug discovery for the development of targeted therapies and diagnostics. Its ability to be conjugated to various molecules through Click chemistry enables the creation of novel drug candidates and imaging agents for studying disease mechanisms and monitoring therapeutic responses.
Used in Material Science:
FAM alkyne, 5-isomer is used in material science for the development of functional materials with tailored properties. The copper-catalyzed Click chemistry allows for the precise assembly of FAM alkyne, 5-isomer with other components, enabling the creation of advanced materials for applications such as sensing, imaging, and drug delivery.

Check Digit Verification of cas no

The CAS Registry Mumber 510758-19-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,0,7,5 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 510758-19:
(8*5)+(7*1)+(6*0)+(5*7)+(4*5)+(3*8)+(2*1)+(1*9)=137
137 % 10 = 7
So 510758-19-7 is a valid CAS Registry Number.

510758-19-7Relevant articles and documents

Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Chen, Yefeng,Xu, Minqiu,Xu, Weipan,Song, Heng,Hu, Liqiang,Xue, Shuyuan,Zhang, Shuangzhan,Qian, Xiana,Xie, Hexin

, p. 9919 - 9922 (2019)

Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.

Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors

Gampe, Christian M.,Tsukamoto, Hirokazu,Doud, Emma H.,Walker, Suzanne,Kahne, Daniel

supporting information, p. 3776 - 3779 (2013/04/23)

New antibiotic drugs need to be identified to address rapidly developing resistance of bacterial pathogens to common antibiotics. The natural antibiotic moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases

CHEMOENZYMATIC METHODS FOR SYNTHESIZING MOENOMYCIN ANALOGS

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Paragraph 00154; 00155, (2013/10/22)

The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I).

METHODS AND COMPOUNDS FOR IDENTIFYING GLYCOSYLTRANSFERASE INHIBITORS

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Paragraph 00223; 00233-00234, (2013/10/22)

The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using compounds of Formula (I).

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