2450-71-7

Basic information

• Product Name: 2-Propynylamine
• Synonyms: Propargulamine;POTASSIUM TER-BUTOXIDE;Prop-2-yn-1-amine;Prop-2-ynylamine, tech. (mono-Propargylamine);2-Propynylamine, 3-Amino-1-propyne;Propargylamine ,98%;Propargylamine,99%;Propargylamin
• CAS NO: 2450-71-7
• Molecular Formula: C₃H₅N
• Molecular Weight: 55.08
• EINECS: 219-513-8
• Product Categories: Amines;blocks;Amines and Anilines;Acetylenes;Functionalized Acetylenes
• Mol File: 2450-71-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 84 °C
• Flash Point: 39 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.86
• Refractive Index: n20/D 1.449(lit.)
• Storage Temp.: 2-8°C
• PKA: 7.89±0.29(Predicted)
• Water Solubility: miscible
• Sensitive: Air Sensitive
• BRN: 773681
• CAS DataBase Reference: 2-Propynylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynylamine(2450-71-7)
• EPA Substance Registry System: 2-Propynylamine(2450-71-7)

Safety Data

• Hazard Codes: F,T
• Statements: 11-22-24-34
• Safety Statements: 16-26-33-36/37/39-45-28A
• RIDADR: UN 1992 3/PG 2
• WGK Germany: 3
• RTECS: UK5250000
• F: 3-8-10-34
• TSCA: Yes
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 2450-71-7(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Different sources of media describe the Uses of 2450-71-7 differently. You can refer to the following data:
1. A useful intermediates in the preparation of drugs or pesticides.
2. Propargylamine is used in the synthesis of a chiral, a fluorescent macrocycle by 1,3-dipolar cycloaddition of propargyl amides of carbohydrate-linked amino acids and 9,10-bis(azidomethyl)anthracene. It acts as an intermediate in the production of drugs.
3. Synthesis of a chiral, fluorescent macrocycle by 1,3-dipolar cycloaddition of propargyl amides of carbohydrate-linked amino acids and 9,10-bis(azidomethyl)anthracene.

Enzyme inhibitor

This alkynyl amine HCCCH2–NH2 (FWfree-base = 55.08 g/mol), also known as propargylamine and 3-amino-1-propyne, is a toxic liquid that boils at 83°C. The water-soluble hydrochloride melts at 179-182°C. Target(s): aldehyde dehydrogenase; diamine oxidase, or amine oxidase [copper-containing]; glycine cleavage complex, or glycine synthase; and monoamine oxidase, or amine oxidase [flavin-containing].

InChI:InChI=1/C3H5N/c1-2-3-4/h4H2,1H3

Upstream product

• 6165-76-0 propargyl p-toluenesulfonate 
• 106-96-7 propargyl bromide 
• 22483-20-1 [2-Methyl-prop-(E)-ylidene]-prop-2-ynyl-amine 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 
• 40152-81-6 2,3-dibromopropan-1-amine 
• 141-52-6 sodium ethanolate 
• 14989-89-0 3-azido-1-propyne 
• 146039-12-5 N-propargyltriethoxyiminophosphorane 
• 7223-50-9 N-propargylphthalimide 

Downstream Products

• 35161-71-8 methyl(propargyl)amine 
• 107-19-7 propargyl alcohol 
• 4943-83-3 2-amino-N-(prop-2-yn-1-yl)benzamide 
• 32956-98-2 5,5-diphenyl-2-prop-2-ynylamino-oxazol-4-one 
• 52829-88-6 5-methylene-N-phenyl-4,5-dihydrothiazol-2-amine 
• 6921-28-4 dipropargylamine 
• 29091-35-8 N³,N³-Dimethyl-2,4-dinitro-N¹-prop-2-ynyl-6-trifluoromethyl-benzene-1,3-diamine 
• 10442-03-2 4-propargylthiomorpholine-1,1-dioxide 
• 25385-15-3 N-Propin-(2)-yl-2,2-diethyl-1,3-dicarbamoyloxy-propan 
• 25384-98-9 N-Propin-(2)-yl-2-methyl-2-isopropyl-1,3-dicarbamoyloxy-propan 
• 25385-11-9 N-Propin-(2)-yl-2-methyl-2-isobutyl-1,3-dicarbamoyloxy-propan 
• 25385-14-2 N-Propin-⁽²⁾yl-2-methyl-2-phenyl-1,3-dicarbamoyloxy-propan 
• 32962-48-4 5-(2-fluoro-phenyl)-2-prop-2-ynylamino-oxazol-4-one 
• 56096-28-7 2-(N-prop-2-ynylamino)acetonitrile 

Relevant articles and documents

N-Propargyltrifluoromethanesulfonamide

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Design and Synthesis of Oleanolic Acid Trimers to Enhance Inhibition of Influenza Virus Entry

Influenza is a major threat to millions of people worldwide. Entry inhibitors are of particular interest for the development of novel therapeutic strategies for influenza. We have previously discovered oleanolic acid (OA) to be a mild influenza hemagglutinin (HA) inhibitor. In this work, inspired by the 3D structure of HA as a homotrimeric receptor, we designed and synthesized 15 OA trimers with different linkers and central region via the copper-catalyzed azide-alkyne cycloaddition reaction. All of the OA trimers were evaluated for their antiviral activities in vitro, and 12c, 12e, 13c, and 13d were observed to exhibit robust potency (IC50 in the submicromolar range) against influenza A/WSN/33 (H1N1) virus that was stronger than that observed with oseltamivir. In addition, these compounds also displayed strong biological activity against A/Hong Kong/4801/2014 and B/Sichuan/531/2018 (BV). The results of hemagglutination inhibition assays and surface plasmon resonance binding assays suggest that these OA trimers may interrupt the interaction between the HA protein of influenza virus and the host cell sialic acid receptor, thus blocking viral entry. These findings highlight the utility of multivalent OA conjugates to enhance the ligand-target interactions in anti-influenza virus drug design and are also helpful for studying antiviral drugs derived from natural products.

O -Phthalaldehyde catalyzed hydrolysis of organophosphinic amides and other P(O)-NH containing compounds

Over 50 years ago, Jencks and Gilchrist showed that formaldehyde catalyses the hydrolysis of phosphoramidate through electrophilic activation, induced by covalent attachment to its nitrogen atom. Given our interest in the use of aldehydes as catalysts, this work was revisited to identify a superior catalyst, o-phthalaldehyde, which facilitates hydrolyses of various organophosphorus compounds bearing P(O)-NH subunits under mild conditions. Interestingly, chemoselective hydrolysis of the P(O)-N bonds could be accomplished in the presence of P(O)-OR bonds.