511254-92-5

Basic information

• Product Name: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)
• Synonyms: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI);(2S)-1-BENZYL-2-METHYLPIPERAZINE
• CAS NO: 511254-92-5
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28472
• Product Categories: PIPERIDINE
• Mol File: 511254-92-5.mol

Chemical Properties

• Boiling Point: 282℃
• Flash Point: 112℃
• Appearance: /
• Density: 0.991
• Vapor Pressure: 0.00354mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.29±0.40(Predicted)
• CAS DataBase Reference: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)(511254-92-5)
• EPA Substance Registry System: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)(511254-92-5)

Safety Data

• Hazardous Substances Data: 511254-92-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)(9CI) is used as a building block for the development of various drugs due to its unique structural features and potential biological activity. Its presence in the pharmaceutical industry is attributed to its ability to form a wide range of compounds with diverse therapeutic applications.
Used in Drug Design and Synthesis:
Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)(9CI) is used as a key component in drug design and synthesis, where its unique properties and spatial arrangement can be leveraged to create new and effective medications. The presence of the methyl and phenylmethyl groups in the 2nd position of the piperazine ring may contribute to the compound's ability to interact with specific biological targets, potentially leading to the development of novel therapeutic agents.

InChI:InChI=1/C12H18N2/c1-11-9-13-7-8-14(11)10-12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3/t11-/m0/s1

Upstream product

• 100-39-0 benzyl bromide 
• 147081-29-6 (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 716339-52-5 tert-butyl (3S)-4-benzyl-3-methylpiperazine-1-carboxylate 

Downstream Products

• 511254-95-8 (S)-1-benzyl-4-(4-chlorophenyl)-2-methylpiperazine 
• 337530-42-4 (3S)-1-(4-chlorophenyl)-3-methylpiperazine 
• 1018829-34-9 (2S)-1-benzyl-4-(4-((2S)-4-benzyl-2-methylpiperazin-1-yl)-2-methylphenyl)-2-methylpiperazine 
• 869725-68-8 (S)-tert-butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-cyanopiperidine-1-carboxylate 
• 306296-78-6 tert-butyl-4-methyl-4-[(3S)-3-methylpiperazin-1-yl]piperidine-1-carboxylate 
• 716339-53-6 (S)-tert-butyl 4-(4-benzyl-3-methylpiperazin-1-yl)-4-methylpiperidine-1-carboxylate 

Relevant articles and documents

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

Piperazine derivatives

This invention relates to novel compounds that are piperazine derivatives, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel piperazine compounds that are derivatives of the chemokine CCR5 receptor antagonist

Synthesis and structure of 1,4-dipiperazino benzenes: Chiral terphenyl-type peptide helix mimetics

(Chemical Equation Presented) The terphenyl structure has been proven to be an ideal scaffold mimicking side-chain functionalities of peptidic α-helices. The synthesis of 1,4-dipiperazino benzenes, using stepwise transition metal-catalyzed N-arylation of chiral piperazines to a central benzene core is reported. The structure determination by X-ray crystallography reveals a geometrical arrangement of the hydrophobic side chains resembling the orientation of key i, i + 3, and i + 7 positions in a peptidic α-helix or in terphenyl helix mimetics.

Piperazinylpiperidine derivatives as chemokine receptor antagonists

The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR

Piperidine derivatives useful as CCR5 antagonists

The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing