- N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS
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The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.
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Page/Page column 200; 201
(2015/07/07)
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- FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF
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The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.
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Page/Page column 76
(2012/07/14)
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- GENERAL ROUTES TO 4-OXO-4H-PYRANOPYRIDINE-3-CARBOXYLATES AND RELATED COMPOUNDS: SYNTHESIS OF THE OXYGEN AND SULFUR ISOSTERES OF NALIDIXIC ACID
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Imidazolides of 2-hydroxy- and 2-mercaptonicotinic acids with LiCH2CO2Bu-t gave ketoesters which were cyclised with MeOCH=NMe2+ MeOSO3- and i-Pr2NEt or with (RCO)2O-NEt3-DMAP to the title 2-H or 2-R bicyclic esters; the corresponding
- McCombie, Stuart W.,Lin, Sue-Ing,Tagat, Jayaram R.
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- Aza Analogues of Lucanthone: Synthesis and Antitumor and Bactericidal Properties
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Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs.None of the compounds was found to have significant cytotoxic effects either on Friend tumor cells or on L1210 leukemia cells.However, one of the target compound
- Croisy-Delcey, Martine,Bisagni, Emile
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p. 1329 - 1333
(2007/10/02)
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