51146-04-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-6-methylpyridine-3-carboxylic acid ethyl ester is used as a building block for the synthesis of various drug molecules. Its unique structure and functional groups make it a valuable intermediate in the development of new pharmaceuticals, contributing to the creation of innovative treatments and therapies.
Used in Agricultural Chemicals:
In the agricultural sector, 2-Hydroxy-6-methylpyridine-3-carboxylic acid ethyl ester serves as a precursor in the production of pesticides and other agricultural chemicals. Its role in these applications is crucial for enhancing crop protection and improving overall agricultural productivity.
Safety Considerations:
It is important to handle 2-Hydroxy-6-methylpyridine-3-carboxylic acid ethyl ester with caution and follow proper safety protocols due to its potential health hazards. The ethyl ester form of 2-Hydroxy-6-methylpyridine-3-carboxylic acid ethyl ester allows for easier handling and storage compared to the free acid form, reducing the risks associated with its use in various applications.

InChI:InChI=1/C9H11NO3/c1-3-13-9(12)7-5-4-6(2)10-8(7)11/h4-5H,3H2,1-2H3,(H,10,11)

Upstream product

• 38116-61-9 2-hydroxy-6-methylnicotinic acid 
• 64-17-5 ethanol 
• 86129-62-6 ethyl 1,2-dihydro-2-oxo-4-chloro-6-methylpyridine-3-carboxylate 
• 10350-10-4 ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate 

Downstream Products

• 39073-14-8 ethyl 2-chloro-6-methyl-3-pyridinecarboxylate 
• 84703-18-4 5-bromo-2-chloro-6-methylpyridine-3-carbonitrile 
• 883241-16-5 6-methyl-2-(4-trifluoromethylphenyl)nicotinic acid 

Relevant academic research and scientific papers

N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS

The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.

FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF

The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

GENERAL ROUTES TO 4-OXO-4H-PYRANOPYRIDINE-3-CARBOXYLATES AND RELATED COMPOUNDS: SYNTHESIS OF THE OXYGEN AND SULFUR ISOSTERES OF NALIDIXIC ACID

Imidazolides of 2-hydroxy- and 2-mercaptonicotinic acids with LiCH2CO2Bu-t gave ketoesters which were cyclised with MeOCH=NMe2+ MeOSO3- and i-Pr2NEt or with (RCO)2O-NEt3-DMAP to the title 2-H or 2-R bicyclic esters; the corresponding

Aza Analogues of Lucanthone: Synthesis and Antitumor and Bactericidal Properties

Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs.None of the compounds was found to have significant cytotoxic effects either on Friend tumor cells or on L1210 leukemia cells.However, one of the target compound