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51165-09-4

SUBSTANCE P (5-11) is a neuropeptide fragment derived from the larger peptide substance P, consisting of the amino acids phenylalanine, glycine, and leucine. It functions as a neurotransmitter in the central nervous system, playing a crucial role in the transmission of pain signals and the regulation of inflammation and immune responses. Its potential therapeutic applications are being explored for pain management and neuroinflammatory conditions, with implications in the pathophysiology of chronic pain, arthritis, and neurodegenerative diseases.

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  • 51165-09-4 Structure

  • Basic information

    1. Product Name: SUBSTANCE P (5-11)
    2. Synonyms: HEPTA-SUBSTANCE P;H-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P (5-11);substance P fragment 5-11;Substance-P-(5-11) Hepta-Substance P;L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2;L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
    3. CAS NO:51165-09-4
    4. Molecular Formula: C41H60N10O9S
    5. Molecular Weight: 869.04
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 51165-09-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 1375.5°Cat760mmHg
    3. Flash Point: 785.6°C
    4. Appearance: /
    5. Density: 1.265g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.581
    8. Storage Temp.: -15°C
    9. Solubility: N/A
    10. CAS DataBase Reference: SUBSTANCE P (5-11)(CAS DataBase Reference)
    11. NIST Chemistry Reference: SUBSTANCE P (5-11)(51165-09-4)
    12. EPA Substance Registry System: SUBSTANCE P (5-11)(51165-09-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 51165-09-4(Hazardous Substances Data)

51165-09-4 Usage

Uses

Used in Pharmaceutical Industry:
SUBSTANCE P (5-11) is used as a therapeutic agent for its potential in pain management and the treatment of neuroinflammatory conditions. Its role in modulating pain signals and immune responses makes it a promising candidate for the development of new treatments for chronic pain, arthritis, and neurodegenerative diseases.
Used in Research and Development:
In the field of biomedical research, SUBSTANCE P (5-11) is utilized as a target for studying the underlying mechanisms of pain transmission and neuroinflammation. Further research on this neuropeptide may contribute to a better understanding of the pathophysiology of various pain-related and inflammatory disorders, potentially leading to the discovery of novel therapeutic approaches.

Check Digit Verification of cas no

The CAS Registry Mumber 51165-09-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,1,6 and 5 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 51165-09:
(7*5)+(6*1)+(5*1)+(4*6)+(3*5)+(2*0)+(1*9)=94
94 % 10 = 4
So 51165-09-4 is a valid CAS Registry Number.
InChI:InChI=1/C41H60N10O9S/c1-24(2)20-30(40(59)48-28(36(45)55)18-19-61-3)47-35(54)23-46-38(57)31(21-25-10-6-4-7-11-25)50-41(60)32(22-26-12-8-5-9-13-26)51-39(58)29(15-17-34(44)53)49-37(56)27(42)14-16-33(43)52/h4-13,24,27-32H,14-23,42H2,1-3H3,(H2,43,52)(H2,44,53)(H2,45,55)(H,46,57)(H,47,54)(H,48,59)(H,49,56)(H,50,60)(H,51,58)/t27-,28-,29-,30-,31-,32-/m0/s1

51165-09-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name SUBSTANCE P (5-11)

1.2 Other means of identification

Product number -
Other names L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51165-09-4 SDS

51165-09-4Relevant articles and documents

4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds): a New Protecting Group of the Guanidino Function in Peptide Synthesis

Fujino, Masahiko,Nishimura, Osamu,Wakimasu, Mitsuhiro,Kitada, Chieko

, p. 668 - 669 (2007/10/02)

The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group for the protection of the guanidino function, which is readily removed with trifluoroacetic acid-thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH-RH analogues.

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