78700-61-5Relevant academic research and scientific papers
Synthesis and Radioiodination of Analogues of Substance P for the Building up of a Radioimmunoassay
Bienert, M.,Schmidt, H. E.,Ehrlich, A.,Forner, K.,Klauschenz, E.,et al.
, p. 97 - 100 (2007/10/02)
The substance P (SP) analogs 3>-SP, 8>-SP, 8, Nle11>-SP and 1>-SP have been synthesized by classical methods of peptide synthesis as well as by the liquid phase peptide synthesis (LPPS) to allow conjugation with protein in the Nα-position and radioiodination. 8>-SP and 1>-SP have been radioiodinated by the chloramine T- and the lactoperoxidase method.A complete S-oxidation of SP was observed, when the chloramine T procedure was used, but this modification does not disturbe the assay.The introduction of the 1>-SP-tracer led to considerable improvements of our SP-radioimmunoassay.
