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512177-36-5

2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-

    Cas No: 512177-36-5

  • USD $ 1.9-2.9 / Gram

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  • 512177-36-5 Structure

  • Basic information

    1. Product Name: 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-
    2. Synonyms: 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-;3-acetyl-2-cyclohexyl-1-(4-ethylphenyl)-4-hydroxy-2H-pyrrol-5-one
    3. CAS NO:512177-36-5
    4. Molecular Formula: C20H25NO3
    5. Molecular Weight: 327.42
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 512177-36-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 487.49°C at 760 mmHg
    3. Flash Point: 248.625°C
    4. Appearance: /
    5. Density: 1.209g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.597
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-(512177-36-5)
    12. EPA Substance Registry System: 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-(512177-36-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 512177-36-5(Hazardous Substances Data)

512177-36-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 512177-36-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,2,1,7 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 512177-36:
(8*5)+(7*1)+(6*2)+(5*1)+(4*7)+(3*7)+(2*3)+(1*6)=125
125 % 10 = 5
So 512177-36-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H25NO3/c1-3-14-9-11-16(12-10-14)21-18(15-7-5-4-6-8-15)17(13(2)22)19(23)20(21)24/h9-12,15,18,23H,3-8H2,1-2H3

512177-36-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-1,5-dihydro-3-hydroxy-

1.2 Other means of identification

Product number -
Other names 4-acetyl-5-cyclohexyl-1-(4-ethylphenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:512177-36-5 SDS

512177-36-5Downstream Products

512177-36-5Relevant articles and documents

Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2

Ortiz Zacarías, Natalia V.,Van Veldhoven, Jacobus P. D.,Portner, Laura,Van Spronsen, Eric,Ullo, Salviana,Veenhuizen, Margo,Van Der Velden, Wijnand J. C.,Zweemer, Annelien J. M.,Kreekel, Roy M.,Oenema, Kenny,Lenselink, Eelke B.,Heitman, Laura H.,Ijzerman, Adriaan P.

, p. 9146 - 9161 (2018/10/24)

The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most chemokine receptors, including the close homologue CCR1. By using [3H]CCR2-RA-[R], a high-affinity, CCR2 intracellular ligand, we report an intracellular binding site in CCR1, where this radioligand also binds with high affinity. In addition, we report the synthesis and biological characterization of a series of pyrrolone derivatives for CCR1 and CCR2, which allowed us to identify several high-affinity intracellular ligands, including selective and potential multitarget antagonists. Evaluation of selected compounds in a functional [35S]GTPγS assay revealed that they act as inverse agonists in CCR1, providing a new manner of pharmacological modulation. Thus, this intracellular binding site enables the design of selective and multitarget inhibitors as a novel therapeutic approach.

Pyrrolidinone derivatives

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Page column 21-22, (2010/02/06)

The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.

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