512180-22-2

Basic information

• Product Name: 2-(2,4-Difluoro-phenyl)-quinoline
• Synonyms: 2-(2,4-Difluoro-phenyl)-quinoline
• CAS NO: 512180-22-2
• Molecular Formula: C₁₅H₉F₂N
• Molecular Weight: 241.2354664
• Mol File: 512180-22-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,4-Difluoro-phenyl)-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Difluoro-phenyl)-quinoline(512180-22-2)
• EPA Substance Registry System: 2-(2,4-Difluoro-phenyl)-quinoline(512180-22-2)

Safety Data

• Hazardous Substances Data: 512180-22-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
2-(2,4-Difluoro-phenyl)-quinoline is used as an anticancer agent for its ability to inhibit the growth of cancer cells. Its potential in this application is attributed to its interaction with specific biological targets, thereby disrupting cancer cell proliferation and survival mechanisms.
Used in Optoelectronic Applications:
In the field of optoelectronics, 2-(2,4-Difluoro-phenyl)-quinoline is utilized for its fluorescent properties, making it a potential candidate for the development of organic light-emitting diodes (OLEDs) and other optoelectronic devices. Its incorporation in these devices can enhance their performance and efficiency.
Used in Materials Science:
2-(2,4-Difluoro-phenyl)-quinoline is also explored in materials science for its potential to contribute to the development of new materials with unique properties. Its chemical structure allows for various modifications and functionalizations, expanding its applicability in creating advanced materials for diverse uses.

Upstream product

• 2005-43-8 2-bromoquinoline 
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• 552-89-6 2-nitro-benzaldehyde 
• 364-83-0 2',4'-difluoroacetophenone 
• 612-62-4 2-Chloroquinoline 
• 288101-48-4 2-(2,4-difluorophenyl)-4,4, 5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

High color rendering index in phosphorescent white organic light-emitting diodes using a yellowish-green dopant with broad light emission

High color rendering index phosphorescent white organic light-emitting diodes (PHWOLEDs) were developed using a yellowish green dopant with broad light emission. A yellowish green phosphorescent dopant derived from difluorophenylquinoline ligand was synthesized and showed maximum emission peak at 550 nm and broad light emission with a full width at half maximum of 77 nm in addition to high quantum efficiency of 20.5%. The yellowish green dopant was used in PHWOLEDs to enhance the color rendering index and high color rendering index of 86.8 was obtained with a high quantum efficiency of 15.7%.

Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process

A continuous photochemical process is presented that renders a series of quinoline products via an alkene isomerization and cyclocondensation cascade. It is demonstrated that a high-power LED lamp generates the desired targets with higher productivity and efficiency than a medium-pressure Hg-lamp. The scope of this tandem process is established and allows for the generation of various substituted quinolines in high yields and with throughputs of greater than one gram per hour. Finally, this effective flow process is coupled with a telescoped hydrogenation reaction to render a series of tetrahydroquinolines including the antimalarial natural product galipinine.

Silver-Catalyzed Reduction of Quinolines in Water

A ligand- and base-free silver-catalyzed reduction of quinolines and electron-deficient aromatic N-heteroarenes in water has been described. Mechanistic studies revealed that the effective reducing species was Ag-H. This versatile catalytic protocol provided facile, environmentally friendly, and practical access to a variety of 1,2,3,4-tetrahydroquinoline derivatives at room temperature.

Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: Coordination and photo-induced oxidation

Amyloidogenic peptides are considered central pathological contributors towards neurodegeneration as observed in neurodegenerative disorders [e.g., amyloid-β (Aβ) peptides in Alzheimer's disease (AD)]; however, their roles in the pathologies of such diseases have not been fully elucidated since they are challenging targets to be studied due to their heterogeneous nature and intrinsically disordered structure. Chemical approaches to modify amyloidogenic peptides would be valuable in advancing our molecular-level understanding of their involvement in neurodegeneration. Herein, we report effective chemical strategies for modification of Aβ peptides (i.e., coordination and coordination-/photo-mediated oxidation) implemented by a single Ir(iii) complex in a photo-dependent manner. Such peptide variations can be achieved by our rationally designed Ir(iii) complexes (Ir-Me, Ir-H, Ir-F, and Ir-F2) leading to significantly modulating the aggregation pathways of two main Aβ isoforms, Aβ40 and Aβ42, as well as the production of toxic Aβ species. Overall, we demonstrate chemical tactics for modification of amyloidogenic peptides in an effective and manageable manner utilizing the coordination capacities and photophysical properties of transition metal complexes.

IRIDIUM COMPLEX, COMPOSITION HAVING THE SAME, AND USE THEREOF

The present invention relates to an iridium complex which is a compound represented by chemical formula 1, a composition comprising an iridium complex, and uses thereof. In the chemical formula 1, R^1 to R^8, and A are as defined in claim 1. The present invention can provide the iridium complex that can be effectively applied to the regulation of amyloid beta peptide aggregation.(AA) [Strategy 1] Inhibition(BB) [Strategy 2] OxidationCOPYRIGHT KIPO 2020

Ionic iridium phosphorescent complex and preparation method thereof

The invention discloses an ionic iridium phosphorescent complex and a preparation method thereof. The ionic iridium phosphorescent complex is characterized by using 2-(2,4-difluorophenyl)quinoline as a main ligand and 4,4'-di(3,5-dimethylphenyl)-2,2'-bipy

Efficient binary white light-emitting polymers grafted with iridium complexes as side groups

Efficient binary white-light-emitting electrophosphorescent copolymers were designed and synthesized via Suzuki polymerization. These copolymers were constructed by grafting a small amount of fluorinated iridium complexes as the side chain of the poly(flu