364-83-0

Basic information

• Product Name: 2',4'-Difluoroacetophenone
• Synonyms: Acetophenone, 2',4'-difluoro-;2',4'-DIFLUOROACETOPHENONE;2,4-DIFLUOROACETOPHENONE;1-(2,4-DIFLUOROPHENYL)ETHANONE;1-(2,4-difluorophenyl)ethan-1-one;2',4'-Difluoroacetophenone 1-(2,4-Difluorophenyl)ethan-1-one;2,4-Difluoroacetophenone,98%;2',4'-Difluoroacetophenone 98%
• CAS NO: 364-83-0
• Molecular Formula: C₈H₆F₂O
• Molecular Weight: 156.13
• EINECS: 206-667-6
• Product Categories: Other fluorin-contained compounds;Acetophenone Series;Aromatic Acetophenones & Derivatives (substituted);Fluorobenzene;ketone;Adehydes, Acetals & Ketones;Fluorine Compounds;C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 364-83-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 80-81 °C25 mm Hg(lit.)
• Flash Point: 152 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.234 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.488(lit.)
• Storage Temp.: Store below +30°C.
• Water Solubility: INSOLUBLE
• BRN: 1940741
• CAS DataBase Reference: 2',4'-Difluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-Difluoroacetophenone(364-83-0)
• EPA Substance Registry System: 2',4'-Difluoroacetophenone(364-83-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 8
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 364-83-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to yellow liqui

Uses

Different sources of media describe the Uses of 364-83-0 differently. You can refer to the following data:
1. 2'',4''-Difluoroacetophenone
2. 2′,4′-Difluoroacetophenone has been used as starting reagent in the synthesis of difluorinated chalcones.

General Description

Vibrational spectral analysis of 2′,4′-difluoroacetophenone has been carried out by FT-IR and FT-Raman spectroscopy.

Upstream product

• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 75-05-8 acetonitrile 
• 372-18-9 1,3-Difluorobenzene 
• 108-24-7 acetic anhydride 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 348-57-2 2,4-difluorobromobenzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 2267-47-2 1-(2,4-difluorophenyl)ethan-1-ol 
• 64287-17-8 1-(2,4-Difluoro-phenyl)-butane-1,3-dione 
• 219488-04-7 RL₃₉₉ 
• 405196-57-8 4-(2,4-difluoro-phenyl)-4-oxo-butyric acid tert-butyl ester 
• 367-27-1 2,4-difluorophenol 
• 36914-77-9 acetic acid 2,4-difluorophenyl ester 
• 1978-22-9 1-(2,4-difluoro-phenyl)-2,2-difluoro-ethanone 
• 391-89-9 1-(2,4-difluoro-phenyl)-2,2-difluoro-ethanol 
• 474707-70-5 3-(2,4-difluorophenyl)-1H-pyrazole 
• 474708-51-5 4'-fluoro-2'-(2-methoxyethoxy)acetophenone 
• 220996-60-1 2-(2,2,2-trifluoroethoxy)-4-fluoroacetophenone 
• 1481-27-2 4-Fluoro-2-hydroxyacetophenone 
• 98619-07-9 1-(2-fluoro-4-hydroxyphenyl)ethanone 
• 863119-54-4 methyl 6-fluoro-3-methyl-1-benzothiophene-2-carboxylate 

Relevant articles and documents

Promoting charge separation in donor-acceptor conjugated microporous polymers: Via cyanation for the photocatalytic reductive dehalogenation of chlorides

Conjugated microporous polymers (CMPs) have emerged as promising heterogeneous photocatalysts for organic transformations owing to their structural designability and functional versatility. However, limited by the insufficient separation of the photo-generated excitons, their photocatalytic efficiency falls far short of expectations. Herein, we demonstrate a cyanation strategy to promote charge carrier separation in CMPs by selectively incorporating carbazole and cyano groups as electron-donating and electron-withdrawing units, respectively. The resulting CMPs feature π-extended donor (D)-acceptor (A) conjugation structures endowing them with distinct semiconducting properties, in which the efficient charge separation and transfer and wide visible-light absorption are facilitated. Compared to the cyano-free counterpart, the cyano-functionalized CMPs showed superior photocatalytic efficiency as exemplified by photocatalytic reductive dehalogenation of chlorides. More prominently, full recyclability of the designed CMPs as well as catalytic activity for at least ten runs without the loss of catalytic performance in photocatalytic reductive dehalogenation of chlorides demonstrated their robustness and sustainability. This journal is

Synthesis of 2-fluorocholine aryl carbonyl compounds

The invention provides a method for synthesizing 2-fluoroarylcarbonyl compounds, which comprises the following steps: converting arylcarbonyl compounds into corresponding carbonyl oxime ether compounds, mildly implementing aryl hydrocarbon chain direct fluoridation of high-selectivity oximido substituent group ortho-position in the presence of a palladium catalyst, a fluoridation reagent and additives, and finally, rehydrolyzing oxime ethers under the action of acid to obtain the 2-fluoroarylcarbonyl compounds. The fluoridation method has the advantages of mild reaction conditions, high substrate adaptability, high fluoridation selectivity and the like, is simple to operate, and has higher application research value.

SAR, cardiac myocytes protection activity and 3D-QSAR studies of salubrinal and its potent derivatives

Salubrinal is a selective inhibitor of endoplasmic reticulum (ER) stress and affords remarkable protection to cardiomyocytes. By studying the structure-activity relationship (SAR) of salubrinal, it was found that modification of the quinoline ring terminus and thiourea unit could confer the compound PP1-24 with markedly enhanced cardioprotective activity (EC 50 2 = 0.741, r2 = 0.991).