51219-18-2

Basic information

• Product Name: BOC-ARG(Z)-OH
• Synonyms: n-a-t-boc-n-omega-cbz-l-arginine;N-ALPHA-T-BUTOXYCARBONYL-N-OMEGA-CARBOBENZOXY-L-ARGININE;OMEGA-BENZYLOXYCARBONYL-N-BOC-L-ARGININE;BOC-N-OMEGA-Z-L-ARGININE;BOC-ARG(Z)-OH;N(ALPHA)-BOC-N(OMEGA)-Z-L-ARGININE;Boc-Arg(Cbz)-OH;Nω-Z-Nα-Boc-L-arginine, Nα-Boc-Nω-Z-L-arginine
• CAS NO: 51219-18-2
• Molecular Formula: C₁₉H₂₈N₄O₆
• Molecular Weight: 408.45
• Product Categories: Amino Acid Derivatives;Arginine [Arg, R];Boc-Amino Acids and Derivative
• Mol File: 51219-18-2.mol

Chemical Properties

• Melting Point: 122-124 °C(Solv: benzene (71-43-2))
• Boiling Point: 569.73 °C at 760 mmHg
• Flash Point: 298.362 °C
• Appearance: /
• Density: 1.262 g/cm³
• Refractive Index: 1.557
• Storage Temp.: Store at 0°C
• PKA: 3.93±0.21(Predicted)
• CAS DataBase Reference: BOC-ARG(Z)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-ARG(Z)-OH(51219-18-2)
• EPA Substance Registry System: BOC-ARG(Z)-OH(51219-18-2)

Safety Data

• Hazardous Substances Data: 51219-18-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C19H28N4O6/c1-19(2,3)29-18(27)22-14(15(24)25)10-7-11-21-16(20)23-17(26)28-12-13-8-5-4-6-9-13/h4-6,8-9,14H,7,10-12H2,1-3H3,(H,22,27)(H,24,25)(H3,20,21,23,26)/t14-/m0/s1

Upstream product

• 35897-34-8 N^α-t-butoxycarbonyl-arginine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 

Downstream Products

• 51219-20-6 [(3S)-1-(benzyloxycarbonylamino-imino-methyl)-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester 
• 51219-20-6 Boc-Arg(Z)> 
• 81344-50-5 Arg(Z)>*HCl 
• 51219-20-6 ((S)-1-{Amino-[(E)-benzyloxycarbonylimino]-methyl}-2-oxo-piperidin-3-yl)-carbamic acid tert-butyl ester 
• 130771-19-6 C₁₉H₂₈N₄O₅ 

Relevant articles and documents

Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

A series of arginine aldehyde inhibitors was designed as transition state (TS) analogues based on the known factor Xa specific substrate Cbz-D- Arg-Gly-Arg-pNA. BnSO2-(D)Arg-Gly-Arg-H (20) was found to be the most potent and selective inhibitor of factor Xa and prothrombinase activity in this series.

Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H

D-Phe-Pro-Arg-H sulfate (GYKI-14166) is a highly active and selective inhibitor of thrombin both in vitro and in vivo. Recent studies on the stability of D-Phe-Pro-Arg-H in neutral aqueous solution at higher temperature have revealed that it is transformed into inactive 5,6,8,9,10,10a-hexahydro-2-(3'-guanidinopropyl)-5-benzyl-6-oxo-imidazo [1,2-a]pyrrolo[2,1-c]pyrazine. No such inactivation could be observed with Boc-D-Phe-Pro-Arg-H (GYKI-14451), but this compound was far less specific than the free peptide as it inhibited thrombin and, for instance, plasmin equally well. Assuming that the transformation of free tripeptide aldehyde, mentioned above, can only be initiated by a primary amino terminus, the N-alkyl derivatives of D-Phe-Pro-Arg-H were prepared. Of the new analogues, D-MePhe-Pro-Arg-H (GYKI-14766) proved to be as highly active and selective anticoagulant as its parent compound and was not inactivated by transformation into a heterocyclic compound.