- Probing hydrogen bonding to bound dioxygen in synthetic models for heme proteins: The importance of precise geometry
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Distal hydrogen bonding in natural dioxygen binding proteins is crucial for the discrimination between different potential ligands such as O2 or CO. In the present study, we probe the chemical requirements for proper distal hydrogen bonding in a series of synthetic model compounds for dioxygen-binding heme proteins. The model compounds 1-Co to 7-Co bear different distal residues. The hydrogen bonding in their corresponding dioxygen adducts is directly measured by pulse EPR spectroscopy. The geometrical requirements for this interaction to take place were found to be narrow and very specific. Only two model complexes, 1-Co and 7-Co, form a hydrogen bond to bound dioxygen, which was characterized in terms of geometry and nature of the bond. The geometry and dipolar nature of this interaction in 1-Co-O2 is more similar to the one in natural cobalt myoglobin (Co-Mb), making 1-Co the best model compound in the entire series.
- Dube, Henry,Kasumaj, Besnik,Calle, Carlos,Felber, Beatrice,Saito, Makoto,Jeschke, Gunnar,Diederich, Francois
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supporting information; experimental part
p. 125 - 135
(2009/07/09)
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- DIARYLSULFONES AS 5-HT2A ANTAGONISTS
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Compounds of formula (I) are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.
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Page/Page column 76
(2008/06/13)
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- ARYLSULFONYLNAPHTHALENE DERIVATIVES AS 5HT2A ANTAGONISTS
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Compounds of formula (I) are potent and selective 5-HT2A antagonists, useful in treatment of a variety of adverse conditions of the CNS.
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Page/Page column 41-42
(2008/06/13)
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- ARYLSULFONYL BENZYL ETHERS AS 5-HT2A ANTAGONISTS
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Compounds of formula (I) are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various CNS disorders.
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Page/Page column 23-24
(2010/11/23)
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