51288-04-1

Basic information

• Product Name: 4-Iodo-1H-benzimidazole
• Synonyms: 4-Iodo-1H-benzimidazole;4-Iodobenzimidazole;4-iodo-1H-benzo[d]iMidazole;1H-BenziMidazole, 7-iodo-;4-Iodo-1H-benzimidazole 95%;7-Iodo-1H-benzimidazole;4-Iodo-1H-benzimidazole95%
• CAS NO: 51288-04-1
• Molecular Formula: C₇H₅IN₂
• Molecular Weight: 244.03
• Product Categories: pharmacetical
• Mol File: 51288-04-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 188-189 °C
• Boiling Point: 438.5 °C at 760 mmHg
• Flash Point: 219 °C
• Appearance: /
• Density: 2.082 g/cm³
• Vapor Pressure: 1.77E-07mmHg at 25°C
• Refractive Index: 1.787
• Storage Temp.: 2-8°C
• PKA: 11.39±0.30(Predicted)
• CAS DataBase Reference: 4-Iodo-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-1H-benzimidazole(51288-04-1)
• EPA Substance Registry System: 4-Iodo-1H-benzimidazole(51288-04-1)

Safety Data

• Hazardous Substances Data: 51288-04-1(Hazardous Substances Data)

Usage

General Description

4-Iodo-1H-benzimidazole is an organic compound with the chemical formula C7H5IN2. It is a benzimidazole derivative that contains an iodine atom attached to the 4th position of the benzene ring. 4-Iodo-1H-benzimidazole has several potential applications in pharmaceutical and agrochemical industries due to its significant biological activities, such as anticancer, antiviral, and antibacterial properties. It is also used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 4-Iodo-1H-benzimidazole is a valuable building block in organic synthesis and drug discovery, making it an important compound for research and development in various fields.

InChI:InChI=1/C7H5IN2/c8-5-2-1-3-6-7(5)10-4-9-6/h1-4H,(H,9,10)

Upstream product

• 83741-35-9 4-bromo-1H-benzo[d]imidazole 
• 1125632-64-5 4⁽⁷⁾-(3,3-diethyltriaz-1-enyl)-benzimidazole 

Downstream Products

• 1126143-96-1 (tetraethyl 4,4',4'',4'''-{[10-(2-(1H-benzimidazol-7-ylethynyl)-5-{[6-(1H-imidazol-1-yl)hexyl]oxy}phenyl)porphyrin-5,15-diyl-κN21,κN22,κN23,κN24]bis-[benzene-2,1,3-triylbis(oxy)]}tetrabutanoato(2-))zinc 

Relevant articles and documents

Probing hydrogen bonding to bound dioxygen in synthetic models for heme proteins: The importance of precise geometry

Distal hydrogen bonding in natural dioxygen binding proteins is crucial for the discrimination between different potential ligands such as O2 or CO. In the present study, we probe the chemical requirements for proper distal hydrogen bonding in a series of synthetic model compounds for dioxygen-binding heme proteins. The model compounds 1-Co to 7-Co bear different distal residues. The hydrogen bonding in their corresponding dioxygen adducts is directly measured by pulse EPR spectroscopy. The geometrical requirements for this interaction to take place were found to be narrow and very specific. Only two model complexes, 1-Co and 7-Co, form a hydrogen bond to bound dioxygen, which was characterized in terms of geometry and nature of the bond. The geometry and dipolar nature of this interaction in 1-Co-O2 is more similar to the one in natural cobalt myoglobin (Co-Mb), making 1-Co the best model compound in the entire series.

ARYLSULFONYL BENZYL ETHERS AS 5-HT2A ANTAGONISTS

Compounds of formula (I) are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various CNS disorders.