Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
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Paragraph 00785; 00790; 00791
(2021/12/08)
The synthesis of highly active thiophene ring-containing chromophore components for photonic polymers based on a newly designed route
2-Aminothiophene derivatives are the key intermediates for the present synthesis. It is known that the synthesis of 2-aminothiophene is troublesome although it is a rather simple heterocycle. In this work, an early report was newly developed as a basis for the efficient synthesis of thiophene-ring-containing chromophore components for photonic polymers. 2-Amino-5-nitrothiophene and 2-amino-3,5-dinitrothiophene were synthesized in excellent yield. After diazotization, the 2-aminothiophene derivatives were directly treated with N-phenyldiethanolamine to afford two-electron push-pull compounds. A similar styryl compound was also prepared. All of these chromophore molecules have further polymerizable hydroxy groups on one end of the molecule. These compounds are currently showing interesting potential in making highly sensitive, nonlinear optical polymeric materials. The Royal Society of Chemistry 1999.
Functional Derivatives of Thiophene. I. Synthesis and 1H-NMR Spectra in the 2-Aminothiophene Series.
The preparation of 2-amino-5-nitrothiophene, 2-formamido-5-nitrothiophene, 2-acetamido-5-nitrothiophene and 2-t-butoxycarbonylamino-5-nitrothiophene are described.Abnormal values of the coupling constants J3,4 had been observed in the 1H-NMR spectra of compounds obtained.
Galvez, C.,Garcia, F.
p. 851 - 853
(2007/10/02)
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