515131-51-8Relevant articles and documents
X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases
Báez-Santos, Yahira M.,Barraza, Scott J.,Wilson, Michael W.,Agius, Michael P.,Mielech, Anna M.,Davis, Nicole M.,Baker, Susan C.,Larsen, Scott D.,Mesecar, Andrew D.
, p. 2393 - 2412 (2014/04/17)
Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infected Ve
Carboxylate binding in polar solvents using pyridylguanidinium salts
Fitzmaurice, Richard J.,Gaggini, Francesca,Srinivasan, Natarajan,Kilburn, Jeremy D.
, p. 1706 - 1714 (2008/02/10)
A series of thiourea and guanidinium derivatives have been prepared and their ability to bind a carboxylate group has been investigated. Guanidinium 33, featuring two additional amides and a pyridine moiety, proved to be the most potent carboxylate bindin