Synthesis of a novel fluorescent probe for estrogen receptor
A novel estradiol-mimetic fluorescent probe 5 was synthesized from diethylstilbestrol (DES, 1), which is useful for probing estrogen receptor (ERα), a prognostic indicator of estrogen-dependent cancers, and for developing a homogeneous fluorescence polarization (FP) assay to identify the ligands of estrogen receptor.
Preparation of the radioiodinated histamine amide of 4-O-(carboxypropyl)-diethylstilbestrol
The mixed anhydride synthesis provides a route to an iodinated form of the synthetic estrogen diethylstilbestrol (DES). Labelling of histamine by the oxidative Chloramine-T method prior to coupling to 4-O-(carboxypropyl)-diethylstilbestrol minimizes radiation damage to the sensitive DES derivative. The radioiodinated derivative has demonstrated binding to an anti-DES serum, thus making possible a potentially useful iodine-based radioimmunoassay for DES.
Johnson Jr.,Cernosek Jr.,Gutierrez-Cernosek
p. 501 - 506
(2007/10/13)
More Articles about upstream products of 51759-74-1