518005-84-0

Basic information

• Product Name: 1-(BIPHENYL-4-YL-PHENYL-METHYL)-PIPERAZINE
• Synonyms: 1-(BIPHENYL-4-YL-PHENYL-METHYL)-PIPERAZINE
• CAS NO: 518005-84-0
• Molecular Formula: C₂₃H₂₄N₂
• Molecular Weight: 328.45
• Mol File: 518005-84-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(BIPHENYL-4-YL-PHENYL-METHYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(BIPHENYL-4-YL-PHENYL-METHYL)-PIPERAZINE(518005-84-0)
• EPA Substance Registry System: 1-(BIPHENYL-4-YL-PHENYL-METHYL)-PIPERAZINE(518005-84-0)

Safety Data

• Hazardous Substances Data: 518005-84-0(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivatives

Structure

Substituted piperazine with a biphenyl and phenyl-methyl groups attached to the piperazine ring

Potential medicinal properties

Wide range of biological activities

Potential use

Drug for various medical conditions, including psychiatric disorders and neurological diseases

Unique chemical structure

Presence of aromatic rings

Research focus

Drug development and further research to explore its therapeutic properties

Upstream product

• 3218-36-8 4-Phenylbenzaldehyde 
• 7598-80-3 4-phenylbenzhydrol 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors

A series of pyrazolo[3,4-d]pyrimidines were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that this class of compounds provide remarkable evidence that they are very specific for human enteroviruses, in particular, coxsackieviruses. Some derivatives proved to be highly effective in inhibiting enterovirus replication at nanomolar concentrations. SAR studies revealed that the phenyl group at the N-1 position and the hydrophobic diarylmethyl group at the piperazine largely influenced the in vitro antienteroviral activity of this new class of potent antiviral agents. It was found that the pyrazolo[3,4-d]pyrimidines with a thiophene substituent, such as compounds 20-24, in general exhibited high activity against coxsackievirus B3 (IC50=0.063-0.089μM) and moderate activity against enterovirus 71 (IC50=0.32-0.65μM) with no apparent cytotoxic effect toward RD (rhabdomyosarcoma) cell lines (CC5025μ M).