- Faurine and O-methylfaurine, two novel benzyl-aporphine dimers from Thalictrum fauriei
-
Two new benzyl-aporphine dimers, faurine (1) and its O-methyl ether (2), were obtained from Thalictrum fauriei and their structures determined by spectral and chemical methods. Faurine (1), the first dimer with the diphenyl ether connection at C-1 of the aporphine, did not undergo a Hofmann degradation, yet formed a chiral phenanthrene product (6) with cyanogen bromide. Two nondimeric chiral aporphine alkaloids, O-acetylisocorydine and O-methylisocorydine, gave the corresponding phenanthrene products 7 and 8, respectively, under the same conditions, but only compound 7 was optically active.
- Lee, Shoei-Sheng,Doskotch, Raymond W.
-
-
Read Online
- Interlayer Shifting in Two-Dimensional Covalent Organic Frameworks
-
Layer-stacking structures are very common in two-dimensional covalent organic frameworks (2D COFs). While their structures are normally determined under solvent-free conditions, the structures of solvated 2D COFs are largely unexplored. We report herein t
- Kang, Chengjun,Zhang, Zhaoqiang,Wee, Vanessa,Usadi, Adam K.,Calabro, David C.,Baugh, Lisa Saunders,Wang, Shun,Wang, Yuxiang,Zhao, Dan
-
supporting information
p. 12995 - 13002
(2020/09/01)
-
- ELECTROCHEMICALLY ACTIVE AGENTS FOR PH MODULATION IN BIOLOGICAL BUFFERS
-
Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent comprising quinone derivatives that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
- -
-
Paragraph 00304
(2017/01/26)
-
- A versatile synthesis of bis[2-(2'-hydroxylphenyl)benzoxazole] derivatives as zinc sensors
-
A versatile synthetic route has been developed to prepare 2, 5-bis(benzoxazole-2-yl)benzene-1,4-diol derivatives 2. Although one of the derivatives (2b) has recently been shown to exhibit an excellent response to Zn2+ cations, the low yielding synthetic route will likely prevent its wide application. This report describes an improved synthetic procedure to obtain 2, thereby making this class of compounds available for biologically relevant studies. An effective synthesis has been developed for 2-aminophenol derivative 6, which bears a carboxylate group in the desired position. The strategy allows construction of bis(benzoxazole) compound 5, where the built-in ester group can be easily converted to either a hydroxymethyl or a bromomethyl group to introduce the zinc-chelating ligand. The Royal Society of Chemistry 2013.
- Wang, Junfeng,Pang, Yi
-
p. 10208 - 10212
(2013/09/02)
-
- Mono and bis(bioreductive) alkylating agents: Synthesis and antitumor activities in a B16 melanoma model
-
Several potentially bis(alkylating) bis(quinones) (3-5) and 1,4- and 1,3-bis(alkylating) monoquinones (6-13) belonging to general structure 2,2'-ethylenebis[5-[(leaving group) methyl]-1,4-benzoquinone] (3-5) and 2,5- and 2,6-bis[(leaving group)methyl]-1,4
- Witiak,Loper,Ananthan,Almerico,Verhoef,Filppi
-
p. 1636 - 1642
(2007/10/02)
-