51832-28-1

Basic information

• Product Name: 1-Methanesulfonylpyrrole
• Synonyms: 1-Methanesulfonylpyrrole
• CAS NO: 51832-28-1
• Molecular Formula: C₅H₇NO₂S
• Molecular Weight: 145.17958
• Mol File: 51832-28-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methanesulfonylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methanesulfonylpyrrole(51832-28-1)
• EPA Substance Registry System: 1-Methanesulfonylpyrrole(51832-28-1)

Safety Data

• Hazardous Substances Data: 51832-28-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Methanesulfonylpyrrole is used as a versatile building block for the preparation of functionalized pyrrole derivatives, which are essential in the development of pharmaceuticals, agrochemicals, and other fine chemicals.
Used in Pharmaceutical Industry:
1-Methanesulfonylpyrrole is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1-Methanesulfonylpyrrole is used as a key intermediate in the synthesis of agrochemicals, playing a role in the creation of effective and safe products for agricultural applications.
Used in Medicinal Chemistry:
1-Methanesulfonylpyrrole is used as a therapeutic agent due to its potential biological activities, which are being studied for their applications in treating various health conditions.
Used in Synthetic Chemistry:
1-Methanesulfonylpyrrole is used for its versatile reactivity, enabling the synthesis of a wide range of chemical compounds with diverse applications in various industries.

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 3144-09-0 methanesulfonamide 
• 109-97-7 pyrrole 
• 124-63-0 methanesulfonyl chloride 
• 108279-49-8 1-methylthiopyrrole 

Downstream Products

• 93289-17-9 1-methanesulfonyl-2-(2-nitrophenyl)pyrrole 
• 1167990-35-3 [N-(methylsulfonyl)pyrrol-2-yl]-(4-methylphenyl)methanone 
• 1269626-74-5 2-methyl-3-((1-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)-4-phenylcyclopent-2-enone 
• 246540-50-1 1-methanesulfonyl-2,5-dihydropyrrole 
• 109-97-7 pyrrole 
• 1591-30-6 (1,1'-biphenyl)-4,4'-dicarbonitrile 
• 1404195-29-4 C₁₃H₁₃IN₂O₂S 

Relevant articles and documents

Integration of oxidative arylation with sulfonyl migration: One-pot tandem synthesis of densely functionalized (NH)-pyrroles

A one-pot synthesis of 2-aryl-3-alkyl/aryl-sulfonyl-(NH)-pyrroles from N-sulfonylpyrroles, developed for the first time, via palladium-catalyzed oxidative C-2 arylation followed by sulfonyl migration is described. The simple, easy access to the highly functionalized free-NH pyrroles secures opportunities for the preparation of compounds with promising biological activities in contemporary organic synthesis. The event of sulfonyl migration from pyrrole-N to C-3 is thermodynamically favored as revealed by density functional methods. The different plausible mechanisms for the migration of the sulfonyl group are also discussed.

Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes

A palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes has been developed. This study unveils that a critical substrate dependent acid concentration is essential for achieving exclusive C-2 selectivity as wel

Pyrrole analogues of chloramphenicol. III. Synthesis and antibacterial activity of

A seven-stage synthesis of a pyrrole analogue of chloramphenicol (9) is described. The compound exhibits a significant antibacterial activity, over the 3% to 50% range of the chloramphenicol activity; over the 6% to 100% range of the thiamphenicol activity and florfenicol.

THE SYNTHESIS OF 1-ALKYLTHIOPYRROLES

Reaction of various S-substituted thiophthalimides or thiosuccinimides and pyrrole, under phase transfer conditions, provides an efficient way to prepare 1-alkylthiopyrroles in high yield.