52010-22-7

Basic information

• Product Name: 4-Chlorophthalide
• Synonyms: 4-Chlorophthalide;1(3H)-Isobenzofuranone, 4-chloro-;Brn 0124386;4-Chloroisobenzofuran-1(3H)-one
• CAS NO: 52010-22-7
• Molecular Formula: C₈H₅ClO₂
• Molecular Weight: 168.00
• Product Categories: Acids and Derivatives;Heterocycles
• Mol File: 52010-22-7.mol

Chemical Properties

• Boiling Point: 360.6 °C at 760 mmHg
• Flash Point: 203.5 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 2.2E-05mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Chlorophthalide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorophthalide(52010-22-7)
• EPA Substance Registry System: 4-Chlorophthalide(52010-22-7)

Safety Data

• Hazardous Substances Data: 52010-22-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Chlorophthalide is utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its chemical properties make it a valuable component in the development of new drugs and agricultural products.
Used in Food and Beverage Industry:
4-Chlorophthalide is employed as a flavoring agent in the food and beverage industry, adding unique taste profiles to various products. Its strong odor contributes to the sensory experience of the final products.
Safety Precautions:
Due to its hazardous nature, appropriate safety measures should be taken when handling 4-Chlorophthalide. It is considered harmful if swallowed, inhaled, or in contact with skin and eyes, requiring proper protective equipment and handling procedures to minimize risks.

InChI:InChI=1/C8H5ClO2/c9-7-3-1-2-5-6(7)4-11-8(5)10/h1-3H,4H2

Upstream product

• 117-21-5 3-chlorophthalic anhydride 
• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 608-23-1 3-chloro-o-xylene 

Downstream Products

• 110706-48-4 3-chloro-1,2-di-(hydroxymethyl)benzene 

Relevant articles and documents

Method for removing impurities from oxidation products

Disclosed is a method for removing impurities from products derived from oxidation of an ortho-dialkylaromatic compound which comprises at least one step selected from the group consisting of extraction of an aqueous solution comprising aromatic dicarboxylic acid product with an organic solvent and extraction of an organic solution comprising aromatic anhydride product with an aqueous bicarbonate solution for a time period insufficient to allow hydrolysis of anhydride to acid.

On the regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides

A problem of 3-methoxyphthalide reduction by metal hydrides was reinvestigated. Various effects controlling selectivity of reductions in 3-substituted phthalides were studied, and a qualitative interpretation of the results is now proposed. Methods for obtaining enhanced yields of one or the other lactonic product were developed.