- Synthesis, Antioxidant, and Anti-Inflammatory Evaluation of Novel Thiophene-Fused Quinoline Based β-Diketones and Derivatives
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Novel thieno[2,3-b]quinoline-2-carboxylic acid derivatives including β-diketone, pyrazole, and flavone were prepared under ultrasonication and evaluated for in vitro antioxidant and anti-inflammatory activities. Antioxidant activity was determined by DPPH
- Mahajan, Pravin,Nikam, Mukesh,Asrondkar, Ashish,Bobade, Anil,Gill, Charansingh
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- Chemistry of substituted quinolines: Thieno[2,3-b] and thiopyrano[2,3-b] quinolines
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The reaction of 3-formyl-2-chloroquinolines with thioglycolic acid afforded a mixture of uncyclized [(3-formylquinolin-2-yl)thio]acetic acid in a 60-70% yield and cyclized thieno[2,3-b]quinoline-2-carboxylic acids in a 30-40% yield, respectively. The uncyclized compounds on refluxing with POCl3 in various alcoholic media gave [(3-formylquinolin-2-yl)thio]acetates. Further cyclization was achieved by refluxing them with dimethylformamide (DMF) to produce thieno[2,3-b]quinoline derivatives. On the other hand, the reaction of 3-formyl-2-mercaptoquinolines with chloroacetyl chloride in DMF gave 3-chloro-2H-thiopyrano[2,3-b]quinolin-2-ones. The structures of all the newly synthesized compounds were characterized on the basis of elemental analysis, IR, 1H NMR, and mass spectral data.
- Kiran, Balaji M.,Nandeshwarappa, Belalakatte P.,Vaidya, Vijayavittala P.,Mahadevan, Kittappa M.
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p. 969 - 980
(2008/02/02)
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