521917-51-1

Basic information

• Product Name: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID
• Synonyms: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID;(3,4-Dihydronaphthalen-2-yl)boronic acid
• CAS NO: 521917-51-1
• Molecular Formula: C10H11BO2
• Molecular Weight: 174
• Mol File: 521917-51-1.mol

Chemical Properties

• Boiling Point: 353.1±52.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.63±0.20(Predicted)
• CAS DataBase Reference: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID(521917-51-1)
• EPA Substance Registry System: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID(521917-51-1)

Safety Data

• Hazardous Substances Data: 521917-51-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1,2-Dihydro-naphthalene-3-boronic acid is used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. Its unique structure and reactivity make it a valuable component in the creation of new and effective molecules for a range of applications.
Used in Fluorescent Dyes and Organic Electronics:
1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID is also utilized in the synthesis of fluorescent dyes and materials for organic electronics. Its ability to form reversible covalent bonds contributes to the development of advanced materials with specific optical and electronic properties.
Used in Medicinal Chemistry:
1,2-Dihydro-naphthalene-3-boronic acid is employed as a versatile reactant in medicinal chemistry for the development of new drugs and pharmaceuticals. Its reactivity and compatibility with various chemical reactions enable the creation of innovative and effective therapeutic agents.

Upstream product

• 92013-27-9 3-bromo-1,2-dihydroxynaphthalene 
• 1056246-70-8 2-bromo-1-tetralone 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 5419-55-6 Triisopropyl borate 
• 64245-04-1 2-bromo-1-hydroxy-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: Towards the design of photoswitchable sirtuin inhibitors

The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound that was originally designed as kinase inhibitor served as a starting point for the design of photoswitchable sirtuin inhibitors. Because the original stilbenoid structure exerted unfavourable photochemical characteristics it was remodelled to its heteroarylic diazeno analogue. By this intramolecular azologization, the shape of the molecule was left unaltered, whereas the photoswitching ability was improved. As anticipated, the highly analogous compound showed similar activity in its thermodynamically stable stretched-out (E)-form. Irradiation of this isomer triggers isomerisation to the long-lived (Z)-configuration with a bent geometry causing a considerably shorter end‐to‐end distance. The resulting affinity shifts are intended to enable real‐time photomodulation of sirtuins in vitro.

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)-pyridines as potent NR1/2B subtype selective NMDA receptor antagonists

A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)- pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. α1 and M 1 receptors) and are active in vivo.

Substituted imidazol-pyridazine derivatives

The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.