92013-27-9

Basic information

• Product Name: 3-BROMO-1,2-DIHYDRONAPHTHALENE
• Synonyms: 3-BROMO-1,2-DIHYDRONAPHTHALENE
• CAS NO: 92013-27-9
• Molecular Formula: C₁₀H₉Br
• Molecular Weight: 209.08246
• Mol File: 92013-27-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 85 °C(Press: 0.01 Torr)
• Appearance: /
• Density: 1.473±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-BROMO-1,2-DIHYDRONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-1,2-DIHYDRONAPHTHALENE(92013-27-9)
• EPA Substance Registry System: 3-BROMO-1,2-DIHYDRONAPHTHALENE(92013-27-9)

Safety Data

• Hazardous Substances Data: 92013-27-9(Hazardous Substances Data)

Upstream product

• 143139-14-4 trifluoromethanesulfonic acid 3,4-dihydronaphthalen-2-yl ester 
• 64245-04-1 2-bromo-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 59867-53-7 2,2-Dimethoxy-1,2,3,4-tetrahydro-naphthalene 
• 1056246-70-8 2-bromo-1-tetralone 
• 105732-48-7 C₁₆H₁₄O₂ 
• 2018-87-3 (+/-)-trans-1,2-dibromo-1,2,3,4-tetrahydronaphthalene 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 

Downstream Products

• 612-78-2 2,2'-binaphthalene 
• 85328-29-6 α,α-diphenyl-2-naphthalene methanol 
• 91-20-3 naphthalene 
• 447-53-0 1,2-Dihydronaphthalene 
• 521917-51-1 (3,4-dihydronaphthalen-2-yl)boronic acid 
• 36230-28-1 2-n-butyltetralin 
• 32367-54-7 2-ethylnaphthalene-1,2,3,4-tetrahydro 
• 85-01-8 phenanthrene 
• 22440-38-6 3,4-dihydronaphthalene-2-carboxylic acid 
• 93-09-4 naphthalene-2-carboxylate 

Relevant articles and documents

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: Towards the design of photoswitchable sirtuin inhibitors

The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound that was originally designed as kinase inhibitor served as a starting point for the design of photoswitchable sirtuin inhibitors. Because the original stilbenoid structure exerted unfavourable photochemical characteristics it was remodelled to its heteroarylic diazeno analogue. By this intramolecular azologization, the shape of the molecule was left unaltered, whereas the photoswitching ability was improved. As anticipated, the highly analogous compound showed similar activity in its thermodynamically stable stretched-out (E)-form. Irradiation of this isomer triggers isomerisation to the long-lived (Z)-configuration with a bent geometry causing a considerably shorter end‐to‐end distance. The resulting affinity shifts are intended to enable real‐time photomodulation of sirtuins in vitro.

Ruthenium-catalyzed transformation of alkenyl triflates to alkenyl halides

In the presence of a ruthenium catalyst, alkenyl triflates were found to be transformed to the corresponding bromides, chlorides and iodides simply by treatment with a lithium halide (1.2 equiv.). The Royal Society of Chemistry 2009.

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)-pyridines as potent NR1/2B subtype selective NMDA receptor antagonists

A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)- pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. α1 and M 1 receptors) and are active in vivo.