Identification of inhibitors of protein kinase B using fragment-based lead discovery
Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 μM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand effi
Saxty, Gordon,Woodhead, Steven J.,Berdini, Valerio,Davies, Thomas G.,Verdonk, Marcel L.,Wyatt, Paul G.,Boyle, Robert G.,Barford, David,Downham, Robert,Garrett, Michelle D.,Carr, Robin A.