522615-28-7

Basic information

• Product Name: 3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID
• Synonyms: AKOS B024955;3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID;ART-CHEM-BB B024955;TIMTEC-BB SBB007287;5-isoxazolecarboxylic acid, 3-(4-fluorophenyl)-4,5-dihydro-;BAS 10826992;MLS000067264;SBB007287
• CAS NO: 522615-28-7
• Molecular Formula: C₁₀H₈FNO₃
• Molecular Weight: 209.17
• Mol File: 522615-28-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID(522615-28-7)
• EPA Substance Registry System: 3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID(522615-28-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 522615-28-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID is used as a building block or intermediate for the synthesis of pharmaceutical compounds due to its unique structural properties and potential biological activities.
Used in Agrochemical Industry:
3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID is used as a precursor or active ingredient in the development of agrochemicals, such as pesticides or herbicides, owing to its potential to influence biological processes in target organisms.
Used in Materials Science:
3-(4-FLUORO-PHENYL)-4,5-DIHYDRO-ISOXAZOLE-5-CARBOXYLIC ACID is used as a component in the development of new materials with specific properties, such as high thermal stability or chemical resistance, due to its structural characteristics.

Upstream product

• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 79-10-7 acrylic acid 
• 1382998-36-8 C₁₂H₁₂FNO₃ 

Downstream Products

• 1174749-28-0 N-[3-(4-{4-(3-(4-fluoro-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide 
• 1407515-81-4 C₁₇H₁₁FN₂O₃ 
• 1394002-25-5 C₁₈H₁₂ClFN₂O₃ 

Relevant articles and documents

Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by 1H NMR, 13C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.

Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial

A series of (5S) N-(3-{3-fluoro-4-[4-(3-aryl-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide(6a-o) were synthesized and their in vitro antibacterial activity against various resistant Gram-positive and Gram-negative bacteria were evaluated. Most of the synthesized compounds showed 2 to 10 fold lower MIC values compared to linezolid against Staphylococcus aureus ATCC 25923, ATCC 70069, ATCC 29213, Bacillus cereus MTCC 430, Enterococcus faecalis MTCC439, Klebsiella pneumoniae ATCC 27736, and Streptococcus pyogens.

Isoxazoline derivatives and plant growth regulators

Novel 3-substituted phenyl-2-isoxazoline-5-carboxylic acids or esters thereof. These compounds have excellent properties as plant growth regulators.