- Synthesis method of 4-phenyl-2-pyrrolidone
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The invention discloses a synthesis method of 4-phenyl-2-pyrrolidone, which comprises the following steps: by using diethyl malonate and 2-nitro-1-phenethyl ketone as raw materials, carrying out condensation reaction by using a strong Lewis base to obtain an intermediate 1, and reacting the intermediate 1 in an organic solvent under the action of palladium-carbon catalytic hydrogenation to obtain an intermediate 3-(3-methoxy carboxyl -4-phenyl-2-pyrrolidone); and finally, carrying out decarboxylation reaction under the alkaline condition of an organic solvent to obtain the final 4-phenyl-2-pyrrolidone. In addition, 4-phenyl-2-pyrrolidone can also be prepared through a Fork alkylation reaction of pyrrolidone and halogenated benzene by a one-step method. The method disclosed by the invention has the characteristics of readily available raw materials, simple reaction conditions, high yield and the like.
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Paragraph 0008; 0024-0027
(2021/04/07)
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- Asymmetric cyanation of activated olefins with ethyl cyanoformate catalyzed by a modular titanium catalyst
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"Chemical Equation Presented" Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5,6, and pharmaceutically Important γ-aminobutyric acid 7.
- Wang, Jun,Li, Wei,Liu, Yanling,Chu, Yangyang,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
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supporting information; experimental part
p. 1280 - 1283
(2010/06/15)
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- Tandem reductive cyclisation of diethyl 2-(2-nitro-1-arylethyl)malonate by zinc and ammonium chloride in aqueous medium
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A tandem reductive cyclisation of diethyl 2-(2-nitro-1-arylethyl)malonate by zinc and ammonium chloride in aqueous medium leading to a one pot synthesis of ethyl 2-oxo-4-arylpyrrolidine-3-carboxylate in good yield has been described.
- Jayapradha,Muthusubramanian
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p. 1645 - 1647
(2008/09/19)
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- PAR2-MODULATING COMPOUNDS AND THEIR USE
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This invention relates to compounds, their uses for the elucidation of PAR2 activity and their uses for the treatment or prevention of diseases or disorders related to PAR2 activity, wherein the compound has the general chemical structure: (I).
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Page/Page column 33
(2008/06/13)
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- Resolution of 4-phenyl-2-pyrrolidinone: A versatile synthetic intermediate
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A resolution of 4-phenyl-2-pyrrolidinone is described. The resulting enantiomerically pure pyrrolidinones are exploited as precursor to 3-phenylpyrrolidines and 3-phenyl-γ-amino acids (4-amino-3-phenylbutanoic acid derivatives).
- Zelle
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p. 1023 - 1026
(2007/10/02)
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