cas 77519-55-2, 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID | Articles data ｜lookchem

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77519-55-2

Articles about 77519-55-2Total 5 be found

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Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen
An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.
Montoya-Balbás, Iris J.,Valentín-Guevara, Berenice,López-Mendoza, Estefanía,Linzaga-Elizalde, Irma,Ordo?ez, Mario,Román-Bravo, Perla
p. 22028 - 22043
(2016/01/25)

Investigation of asymmetric michael addition of meldrum acid to conjugated nitroalkenes carried out in the presence of chiral amines
Nitroalkenes reacted with Meldrum acid in the presence of chiral amines to give the adducts in high yields and limited enantiomeric excesses. The highest enantioselectivity was reached at 20°C in the presence of cinchona alkaloids (ee = 20-25%). Unexpectedly, ee of the product was decreased by temperature lowering.
Kleczkowska,Sas
p. 1457 - 1464
(2008/09/18)

PYRROLIDINE DERIVATIVE OR SALT THEREOF
[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).
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Page/Page column 60

(2008/06/13)

Resolution of 4-phenyl-2-pyrrolidinone: A versatile synthetic intermediate
A resolution of 4-phenyl-2-pyrrolidinone is described. The resulting enantiomerically pure pyrrolidinones are exploited as precursor to 3-phenylpyrrolidines and 3-phenyl-γ-amino acids (4-amino-3-phenylbutanoic acid derivatives).
Zelle
p. 1023 - 1026
(2007/10/02)

THE SYNTHESIS AND ANTISPASMODIC ACTIVITY OF 4-PHENYLPYRROLIDONE-2-ACETAMIDES
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Glozman, O. M.,Morozov, I. S.,Zhmurenko, L. A.,Zagorevskii, V. A.
p. 776 - 780
(2007/10/02)

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Chemical Properties

Boiling Point: 501.6°C at 760 mmHg
Flash Point:257.2°C
Density: 1.301g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 6.99E-11mmHg at 25°C
Refractive Index: 1.58
PSA: 66.40000
LogP: 0.92960

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