- PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
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Disclosed in the present disclosure are a pyrimidine-fused cyclic compound or a pharmaceutically acceptable salt, hydrate, prodrug, stereoisomer, solvate or isotope labeled compound thereof. Also provided in the present disclosure are a preparation method for the compound, a composition comprising the compound and a use of the compound for the preparation of a medicament for the prevention and/or treatment of a disease or condition associated with abnormal SHP2 activity.
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Paragraph 0693-0695
(2021/02/26)
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- Anti-infective compounds
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The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
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Page/Page column 47, 48
(2011/08/04)
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- ANTI - INFECTIVE PYRIDO (1,2 -A) PYRIMIDINES
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The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
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Page/Page column 98; 100-101
(2011/08/04)
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- 4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate
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An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form.
- Ukrainets,Bereznyakova,Petyunin,Tugaibei,Rybakov,Chernyshev,Turov
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p. 729 - 739
(2008/03/11)
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- Methanetricarboxylates as key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity. Part 2 [1]. Reaction of methanetricarboxylates with 2-aminopyridine, 2-aminopyrimidine, 2-aminothiazole and 2-aminobenzothiazole
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The reaction of methanetricarboxylates 1a,b with 2-aminopyridine, 2- aminopyrimidine, 2-aminothiazole as well as 2-aminobenzothiazole yields corresponding heteroarylcarboxylic acid esters 2a,b, 5, 8, 11a,b. These heterocyclic esters were used as a starting material by the reaction with primary amines to obtaining a number of heteroarylcarboxylic amides 4a-j, 6, 10a,b, 13a-g bearing various substituents on the carboxamide group.
- Kutyrev, Alexander,Kappe, Thomas
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p. 237 - 240
(2007/10/03)
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