527681-60-3

Basic information

• Product Name: 3,4-dihydro-2H-Pyrano[2,3-c]pyridine-6-methanol
• Synonyms: 3,4-dihydro-2H-Pyrano[2,3-c]pyridine-6-methanol;(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl)methanol（WS200408）
• CAS NO: 527681-60-3
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.18914
• Mol File: 527681-60-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-dihydro-2H-Pyrano[2,3-c]pyridine-6-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-2H-Pyrano[2,3-c]pyridine-6-methanol(527681-60-3)
• EPA Substance Registry System: 3,4-dihydro-2H-Pyrano[2,3-c]pyridine-6-methanol(527681-60-3)

Safety Data

• Hazardous Substances Data: 527681-60-3(Hazardous Substances Data)

Upstream product

• 724790-39-0 C₁₁H₁₃NO₃ 
• 1356163-58-0 methyl 3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carboxylate 
• 527681-59-0 (8-chloro-2H-pyrano[2,3-c]pyridin-6-yl)methanol 

Downstream Products

• 527681-62-5 3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carboxylic acid 
• 527681-54-5 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carboxamide.fumarate 
• 527681-61-4 3,4-dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde 

Relevant articles and documents

Ruthenium-catalyzed ester reductions applied to pharmaceutical intermediates

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (～5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVATIVES

The present invention relates to a process comprising the step of dehydrating a compound of Formula (I): with a suitable dehydrating reagent to form a compound of Formula (II): wherein R1-R7 as defined herein. Compounds of Formula (I

The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

This Letter describes the synthetic routes to challenging pyridyl analogues of 2,3-dihydro-1,4-benzodioxin- 6-carbaldehyde which were key intermediates for our antibacterial medicinal chemistry programme. All routes described started from kojic acid (8) and have been used to give multigram quantities of each aldehyde.

Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease

The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtures or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which α7 is known to be involved.