527751-48-0 Usage
Derivative of acetophenone
It is a modified version of the parent compound acetophenone, with additional functional groups attached to its aromatic ring.
4-chlorophenyl group
The presence of a chlorine atom attached to the 4-position of the phenyl ring, which influences the compound's chemical reactivity and physical properties.
5'-fluoro group
A fluorine atom is attached to the 5'-position (the meta position) of the aromatic ring, which can affect the compound's reactivity, stability, and biological activity.
Hydroxy group
A hydroxyl (-OH) group is attached to the 2'-position (the ortho position) of the aromatic ring, which can participate in hydrogen bonding and affect the compound's solubility and reactivity.
Carbonyl group
A carbonyl (C=O) functional group is attached to the adjacent carbon atom (the 2-position) of the aromatic ring, which can participate in various chemical reactions and contribute to the compound's biological activity.
Building block in synthesis
2-(4-CHLOROPHENYL)-5'-FLUORO-2'-HYDROXYACETOPHENONE is commonly used as a starting material or intermediate in the synthesis of pharmaceuticals and agrochemicals, due to its versatile chemical structure.
Production of biologically active compounds
The compound's structure allows for the production of various compounds with biological activity, making it a valuable intermediate in the development of new drugs and agrochemicals.
Reference standard in analytical chemistry
2-(4-CHLOROPHENYL)-5'-FLUORO-2'-HYDROXYACETOPHENONE can be used as a reference standard to develop and validate analytical methods, ensuring accurate and reliable results in chemical analyses.
Check Digit Verification of cas no
The CAS Registry Mumber 527751-48-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,2,7,7,5 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 527751-48:
(8*5)+(7*2)+(6*7)+(5*7)+(4*5)+(3*1)+(2*4)+(1*8)=170
170 % 10 = 0
So 527751-48-0 is a valid CAS Registry Number.
527751-48-0Relevant articles and documents
Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-α-methylhistamine: From alkylaryl to substituted diaryl derivatives
Krause,Rouleau,Stark,Garbarg,Schwartz,Schunack
, p. 720 - 726 (2007/10/03)
This study was performed on the basis of recently developed prodrugs of the histamine H3-receptor agonist (R)-α-methylhistamine (1) to determine structure-activity relationships of azomethine prodrugs of 1, in which the primary amine functionality is bioreversibly linked to aromatic ketones. Therefore, the pro-moiety was systematically altered from alkylaryl over benzylaryl to diaryl substitution. Those compounds that emerged to be stable enough during preparation were tested for their in vitro hydrolysis rates. Apparently, bulky alkyl residues were capable of preventing previously observed intramolecular cyclization, but the obtained azomethines 12 a-c were far too unstable to serve as prodrugs. However, the benzylaryl imines 12d, e were stable compounds, but 12d decomposed too rapidly under in vitro conditions. Distinctly greater stability was provided by diaryl pro-moieties, even if strongly electron-withdrawing functionalities were introduced. Selected compounds were also tested in vivo following p.o. application to mice. Particularly the trifluoromethyl substituted imine 12i proved to be highly effective as stability and rate of conversion were well-balanced, so that brain penetration of 1 was strikingly facilitated. Thus 12i, a highly potent azomethine prodrug, may serve as an important pharmacological tool and, possibly, a therapeutic agent.
