5282-89-3

Basic information

• Product Name: Dansyl-ethanolaMine
• Synonyms: Dansyl-ethanolaMine
• CAS NO: 5282-89-3
• Molecular Formula: C₁₄H₁₈N₂O₃S
• Molecular Weight: 294.36932
• Product Categories: Amines, Aromatics, Fluorescent Labels & Indicators, Sulfur & Selenium Compounds
• Mol File: 5282-89-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: Dansyl-ethanolaMine(CAS DataBase Reference)
• NIST Chemistry Reference: Dansyl-ethanolaMine(5282-89-3)
• EPA Substance Registry System: Dansyl-ethanolaMine(5282-89-3)

Safety Data

• Hazardous Substances Data: 5282-89-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Compounds and Inhibitors:
Dansyl-ethanolaMine is used as a key component in the synthesis of pharmaceutical compounds and inhibitors, particularly those with potent antitumor activity. Its unique fluorescent properties allow for easy tracking and monitoring of these compounds during research and development.
Used in Antitumor Compounds:
Dansyl-ethanolaMine is used as a building block for the synthesis of substituted carboxamides, which have demonstrated significant antitumor activity. These compounds have the potential to be developed into effective treatments for various types of cancer.
Used in Anti-plasmodial Agents:
Dansyl-ethanolaMine is also utilized in the synthesis of aminoquinolones, which exhibit anti-plasmodial activity. These agents are crucial in the development of treatments for malaria, a disease that affects millions of people worldwide.

Upstream product

• 605-65-2 5-(dimethylamino)naphth-1-ylsulfonyl chloride 
• 141-43-5 ethanolamine 

Downstream Products

• 64307-60-4 2-(5-(dimethylamino)naphthalene-1-sulfonamido)ethyl 4-methylbenzenesulfonate 
• 35060-08-3 dansylethylenediamine 
• 1041865-45-5 (S)-2-[1-(dimethylamino)naphthalene-5-sulfonamido]ethyl 2-[(2S,3R)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutanamido]-4-methylpentanoate 
• 5354-61-0 5-(dimethylamino)-N-(2-sulfanylethyl)naphthalene-1-sulfonamide 

Relevant articles and documents

Aptamer-based enantioselective competitive binding assay for the trace enantiomer detection

The development of highly enantioselective assays and sensors has received much attention for the determination of enantiomeric impurities at a low level. For chiral compounds, the efficient monitoring of the in selection procedure has allowed the isolation of nucleic acid aptamers which are able to strongly discriminate the target enantiomers. In this paper, we demonstrated for the first time that an aptamer can be successfully used to design a highly enantioselective tool for the trace enantiomer detection. The aptamer-based stereoselective assay was developed using an affinity capillary electrophoresis-based competitive, homogeneous format and an on-capillary mixing approach. Detection of as low as 0.01% of the minor enantiomer in a nonracemic mixture can be achieved, in a short analysis time (5 min).

O-ACETYLETHANOLAMINE, A NATURAL PRODUCT FROM THE LEGUMINOSAE

O-Acetylethanolamine, studied as its dns derivative thruoughout, was isolated from Lens culinaris and identified by spectroscopy/synthesis.Chromatographic evidence indicated its presence in 12 other legumes.Key Word Index - Lens culinaris; Leguminosae; lentil; isolation; amines; ethanolamine; O-acetyl; dansyl chloride.

Powerful probes for glycosidases: Novel, fluorescently tagged glycosidase inhibitors

1-Amino-1,2,5-trideoxy-2,5-imino-D-mannitol was fluorescently tagged by reaction with dansyl chloride at N-1 or by attachment of a dansyl amide bearing spacer to this centre. Compounds obtained are highly potent inhibitors of β-glucosidase exhibiting Ki values in the single figure nanomolar range. The 1-N-dansyl substituted inhibitor was successfully exploited for binding studies with β-glucosidase from Agrobacterium sp. employing fluorescence spectrometric methods.

A new generation of fluorescent chemosensors demonstrate improved analyte detection sensitivity and photobleaching resistance

Molecular chemosensors have found increased utility in the development of precise and sensitive detection devices. However, chemosensors that report binding via fluorescence through UV excitation are susceptible to destruction via photodegradation of the fluorophore. In the following report, the dansyl fluorophore in a previously reported chemosensor for peptides is replaced with an acridone derivative that is highly resistant to photobleaching. Its spectral properties are closely matched to those of the original dansyl fluorophore, and although quite structurally dissimilar, the new more photostable acridone chemosensor analogue exhibits only minor differences in binding/detection characteristics.

Synthesis and photophysical properties of fluorophore-labeled abscisic acid

The 8'-benzophenone, 8'-dansylhydrazone, 3'-S-(2-ethyldansylamide), and 3'-S-acetamidofluorescein derivatives of the plant hormone abscisic acid (ABA) have been synthesized for use in photoaffinity labeling (the benzophenone derivative) or fluorescence pr

METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION

A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a spec

Structure-guided synthesis of a protein-based fluorescent sensor for alkyl halides

Alkyl halides are potentially mutagenic carcinogens. However, no efficient fluorescent sensor for alkyl halide detection in human-derived samples has been developed to date. Herein, we report a new protein-based fluorescent sensor for alkyl halides. Analysis of the HaloTag holo-crystal structure with its covalently attached ligand revealed an unexpected cavity, allowing for the design of a new fluorogenic ligand. This ligand showed the highest fluorescence response (300-fold) and fastest binding kinetics (t1/2 150 s) to a HaloTag mutant (M175P) protein. This protein-based sensor system was effectively used to detect alkyl halides in human serum and monitor real-time protein alkylation.

CELL-PENETRATING, GUANIDINIUM-RICH OLIGOPHOSPHOTRIESTERS FOR DRUG AND PROBE DELIVERY

Guanidinium-rich oligophosphotriesters transporter compounds and methods of making and using the same are provided. Also provided are pharmaceutical compositions that include the subject transporter compounds, where the transporter can be joined to a carg

A novel synthetic strategy for monosubstituted cyclodextrin derivatives

A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (α, β, MeβCD and HPβCD) covalently linked through a phosphodi

Development of target protein-selective degradation inducer for protein knockdown

Our previous technique for inducing selective degradation of target proteins with ester-type SNIPER (Specific and Nongenetic Inhibitor-of-apoptosis- proteins (IAPs)-dependent Protein ERaser) degrades both the target proteins and IAPs. Here, we designed a