1041865-45-5Relevant academic research and scientific papers
Development of target protein-selective degradation inducer for protein knockdown
Itoh, Yukihiro,Ishikawa, Minoru,Kitaguchi, Risa,Sato, Shinichi,Naito, Mikihiko,Hashimoto, Yuichi
experimental part, p. 3229 - 3241 (2011/06/25)
Our previous technique for inducing selective degradation of target proteins with ester-type SNIPER (Specific and Nongenetic Inhibitor-of-apoptosis- proteins (IAPs)-dependent Protein ERaser) degrades both the target proteins and IAPs. Here, we designed a
Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs
Sato, Shinichi,Aoyama, Hiroshi,Miyachi, Hiroyuki,Naito, Mikihiko,Hashimoto, Yuichi
scheme or table, p. 3354 - 3358 (2009/04/05)
Overexpression of cIAP1 correlates with resistance to radiotherapy and chemotherapy in various cancers. Recently, we reported that a class of bestatin ester analogs represented by MeBS (2) destabilized and promoted the degradation of cIAP1 through auto-ub
