- An efficient catalyst for low temperature solid-phase cyclization of poly(o-hydroxyamide)
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An efficient acid catalyst for the low-temperature solid-phase cyclization of poly(o-hydroxyamide) (PHA) has been found. Thermal cyclization of PHA into poly(benzoxazole) (PBO) proceeded quantitatively at 250°C in 10min in the presence of 10 wt % of a photoacitve compound, (5-propylsulfonyloxyimino-5H- thiophen-2-ylidene)-2-(methylphenyl)-acetonitrile (PTMA).
- Toyokawa, Fumihiro,Fukukawa, Ken-Ichi,Shibasaki, Yuji,Ueda, Mitsuru
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Read Online
- Evaluation of O-alkyl and aryl sulfonyl aromatic and heteroaromatic amidoximes as novel potent DNA photo-cleavers
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Several stable O-alkyl and aryl sulfonyl conjugated p-nitro-Ph and o-, m-, p-pyridine N′-hydroxy imidamides, were subjected to UV irradiation at 312 nm with supercoiled circular plasmid DNA pBluescript KS II. The generated amidinyl and sulfonyloxyl radicals led to effective DNA photo-cleavage. Both alkyl and aryl sulfonyl derivatives were active and the order p-pyridine > p-nitro-Ph > o-pyridine > m-pyridine was schematized for the N′-hydroxy imidamides moiety. Calf thymus-DNA affinity studies which comprised UV interactions, viscosity experiments and competitive studies with ethidium bromide showed good to excellent affinity of the compounds. These properties revealed sulfonyl amidoximes as novel effective DNA-photo-cleavers and may serve in the discovery of new leads for "on demand" biotechnological and medical applications.
- Papastergiou,Perontsis,Gritzapis,Koumbis,Koffa,Psomas,Fylaktakidou
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p. 351 - 360
(2016/03/22)
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- Marine bacteria from the Roseobacter clade produce sulfur volatiles via amino acid and dimethylsulfoniopropionate catabolism
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Dimethylsulfoniopropionate (DMSP) is a versatile sulfur source for the production of sulfur-containing secondary metabolites by marine bacteria from the Roseobacter clade. 34S-labelled DMSP and cysteine, and several DMSP derivatives with modified S-alkyl groups were synthesised and used in feeding experiments that gave insights into the biosynthesis of sulfur volatiles from these bacteria. the Partner Organisations 2014.
- Brock, Nelson L.,Menke, Markus,Klapschinski, Tim A.,Dickschat, Jeroen S.
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supporting information
p. 4318 - 4323
(2014/06/23)
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- Selective oxidation reactions of diaryl- and dialkyldisulfides to sulfonic acids by CH3ReO3/hydrogen peroxide
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Diaryl- and dialkyl disulfides were oxidized in acetonitrile at 20 °C by CH3ReO3/H2O2 oxidant system to yield selectively the corresponding sulfonic acids in short reaction times and in high yields.
- Ballistreri, Francesco P.,Tomaselli, Gaetano A.,Toscano, Rosa M.
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experimental part
p. 6231 - 6232
(2010/01/11)
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- Novel benzothiepines having activity as inhibitors of lleal bile acid transport and taurocholate uptake
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Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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- Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
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Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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- Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
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Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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- Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
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Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and EG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
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- Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
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Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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- Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
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Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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- Cyclohexenone derivatives
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Cyclohexenone derivatives I STR1 The cyclohexenone derivatives I are suitable as herbicides and for regulating plant growth.
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- Aminoalkanesulfonic acid derivatives and pharmaceutical compositions for use in preventing or treating heart diseases
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The present invention relates to a pharmaceutical composition for use in preventing or treating heart diseases in a mammal, which comprises at least one aminoalkanesulfonic acid derivative of the formula (I): STR1 wherein X is hydrogen or an amino acid residue; Y is hydrogen, a phenyl group or an alkyl group, which may have a hydroxy, amino, carboxy, phenyl or hydroxyphenyl group; or X and Y are joined to form a trimethylene or hydroxytrimethylene group; and at least one of X and Y is other than hydrogen; or pharmaceutically acceptable salt thereof.
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- The reaction of mercaptans with dimethyldioxirane. A facile synthesis of alkanesulfinic acids
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Dimethyldioxirae oxidizes aliphatic thiols to sulfinic acids in very good yield. Benzylic and aromatic thiols give a variety of other oxidation products using DMD.
- Gu,Harpp
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- Mechanisms of hydrolysis and related nucleophilic displacement reactions of alkanesulfonyl chlorides: pH dependence and the mechanism of hydration of sulfenes
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pH-rate profiles, primary kinetic isotope effects, deuterium substitution patterns, and pH-product ratios in the presence of added nucleophiles provide evidence for the following overlapping set of mechanisms for the hydrolysis of methanesulfonyl chloride (1) (in 0.1 M KCl at 25 °C): (a) pH ≤ 1-6.7, reaction with water by direct nucleophilic attack on the sulfonyl chloride; (b) pH ≥ 6.7-11.8, rate-determining attack by hydroxide anion to form sulfene (2), which is then trapped by water in a fast step; and (c) pH ≥ 11.8, sulfene formation and sulfene trapping by hydroxide anion; careful inspection showed no sign of sulfene formation in the reaction with water or of direct displacement by hydroxide anion. This pattern, with appropriate variations in the values of pHi (the pH at which two competing mechanisms have the same rate), is apparently general for simple alkanesulfonyl chlorides having at least one hydrogen on the carbon bearing the sulfonyl group. Azide and acetate anions react with 1 below pHi for 1 (6.7) by direct nucleophilic substitution at the sulfur, but above pHi by trapping of the sulfene. 2-Chlorophenoxide anion reacts with 1 below pH 6.7 by both (a) direct displacement to form the ester and (b) elimination to form the sulfene. Above pH 6.7, sulfene is formed from the sulfonyl chloride by reaction with either 2-chlorophenoxide or hydroxide ion; this is followed by trapping of the sulfene with 2-chlorophenoxide, water, or hydroxide. The possibility of the 2-chlorophenoxide anion acting as a general base promoting the reaction of water with either 1 and 2 was examined, but no sign of either process was detected.
- King,Lam,Skonieczny
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p. 1743 - 1749
(2007/10/02)
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- MECHANISTIC VARIATION IN ALKANESULFONYL CHLORIDE HYDROLYSIS AND RELATED REACTIONS
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Kinetic and product ratio studies are consistent with the following mechanisms for the hydrolysis of methanesulfonyl chloride: (a) in acidic medium (pH 1-6) via a direct substitution on sulfur (SN2-S), (b) in mildly basic medium (pH 8-10) by way of sulfene (CH2=SO2) formation followed by trapping with water, and (c) in strongly basic solution (pH >10) via sulfene with trapping by the hydroxide ion.The reactions of primary and secondary alkanesulfonyl chlorides are qualitatively similar.
- King, J. F.,Lam, J. Y. L.,Skonieczny, S.
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p. 177 - 180
(2007/10/02)
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- Production of alkanesulfonic acids by oxidation of alkanethiols and dialkyl disulfides
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Alkanesulfonic acids are prepared by oxidation of the corresponding alkanethiol or dialkyl disulfide using an oxygen-containing gas as the oxidizing agent, in the presence of water and catalytic amounts of a lower dialkyl sulfoxide and a hydrogen halide.
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- REACTION OF PROPOSED PHOSPHOROTHIOLATE S-OXIDE INTERMEDIATES WITH ALCOHOLS
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S-Oxide 2 is an extremely reactive intermediate.Its phosphorylation vs rearrangement rates, strongly depend upon the nature of the nucleophile.
- Segall, Yoffi,Casida, John E.
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p. 209 - 212
(2007/10/02)
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- OXIDATIVE CONVERSION OF PHOSPHOROTHIOLATES TO PHOSPHINYLOXYSULFONATES PROBABLY VIA PHOSPHOROTHIOLATE S-OXIDES
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Phosphorothiolate S-oxides and their phosphinyloxysulfenate rearrangement products are probable intermediates in the facile conversion of phosphorothiolates to phosphinyloxysulfonates on peracid oxidation.They may also be intermediates in the biological oxidation of phosphorothiolates.
- Segall, Yoffi,Casida, John E.
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p. 139 - 142
(2007/10/02)
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