5291-18-9

Basic information

• Product Name: 6-methyl-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
• Synonyms: 5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione, 6-methyl-; 6H-Indeno[1,2-c]isoquinoline-5,11-dione, 6-methyl-; 6-Methyl-5H-indeno(1,2-c)isoquinoline-5,11(6H)-dione
• CAS NO: 5291-18-9
• Molecular Formula: C₁₇H₁₁NO₂
• Molecular Weight: 261.2747
• Mol File: 5291-18-9.mol

Chemical Properties

• Boiling Point: 492.5°C at 760 mmHg
• Flash Point: 242.1°C
• Density: 1.39g/cm³
• Vapor Pressure: 7.67E-10mmHg at 25°C
• Refractive Index: 1.721
• CAS DataBase Reference: 6-methyl-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione(5291-18-9)
• EPA Substance Registry System: 6-methyl-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione(5291-18-9)

Safety Data

• Hazardous Substances Data: 5291-18-9(Hazardous Substances Data)

Upstream product

• 958008-18-9 C₁₇H₁₃NO₂ 
• 1285527-74-3 C₁₉H₁₇NO₂ 
• 1285527-71-0 C₁₂H₁₃NO₂ 
• 27326-43-8 2-vinylbenzoic acid 
• 27326-47-2 N-methyl-2-vinylbenzamide 
• 28269-50-3 2-vinylbenzoic acid chloride 
• 107793-07-7 methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 58084-22-3 2-iodo-N-methyl-benzamide 

Relevant articles and documents

Preparation method of indenoisoquinoline derivative

The invention relates to a preparation method of an indenoisoquinoline derivative as shown in formula (I). The preparation method includes the steps of (A), providing a first reactant as shown in formula (II) and a second reactant as shown in formula (III

METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES

A method for preparing indenoisoquinoline derivatives represented by the following formula (I) is disclosed, which comprises the following steps: (A) providing a first reactant represented by the following formula (II) and a second reactant represented by the following formula (III): wherein, R1, R3, A, X, Y, Z, m and n are defined in the specification; and (B) reacting the first reactant represented by the formula (II) and the second reactant represented by the formula (III) in a solvent and selectively adding R2NH2 therein, to obtain the indenoisoquinoline derivatives represented by the formula (I).

Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction

A concise route for the synthesis of indenoisoquinoline derivatives from 2-iodobenzamide and 1,3-indanedione derivatives in the presence of copper(II) chloride and cesium carbonate in acetonitrile solvent is reported. A wide variety of 2-iodobenzamide derivatives and indandiones could be used to synthesize indenoisoquinoline derivatives and other fused indenoisoquinoline in moderate to good yields. This methodology was adapted for the one-step synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400, LMP-776.

Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones

A cobalt-catalyzed dual annulation reaction for the synthesis of variously substituted indenoisoquinolinones from 2-bromobenzaldehydes, amines, and methyl 2-(ethynyl)benzoates has been developed. This method could also be applied to the synthesis of an ar

Suzuki-Miyaura cross-coupling and ring-closing metathesis: A strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones

A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intram

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxici