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Methyl 2-((trimethylsilyl)ethynyl)benzoate is an organic chemical compound characterized by the presence of a benzoate ester group, an ethynyl group, and a trimethylsilyl group. It is a clear, colorless liquid with a slightly fruity odor and is commonly used as an intermediate in the synthesis of other chemical compounds, such as pharmaceuticals and agrochemicals.

107793-07-7

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107793-07-7 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-((trimethylsilyl)ethynyl)benzoate is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Methyl 2-((trimethylsilyl)ethynyl)benzoate is used as a chemical intermediate in the production of agrochemicals, such as pesticides and herbicides. Its versatile chemical properties enable the creation of effective and targeted agricultural products.
Used in Research and Development:
Methyl 2-((trimethylsilyl)ethynyl)benzoate is utilized in research and development for exploring its potential applications in various fields, including material science, chemical synthesis, and drug discovery. Its unique structure and properties make it a valuable compound for scientific investigation.
Used in Industrial Applications:
Methyl 2-((trimethylsilyl)ethynyl)benzoate is employed in various industrial applications due to its chemical properties and reactivity. It can be used in the production of specialty chemicals, coatings, and other materials that require specific properties.
It is important to handle and store methyl 2-((trimethylsilyl)ethynyl)benzoate with caution, following proper safety protocols and regulations to ensure safe usage and minimize potential hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 107793-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,7,9 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 107793-07:
(8*1)+(7*0)+(6*7)+(5*7)+(4*9)+(3*3)+(2*0)+(1*7)=137
137 % 10 = 7
So 107793-07-7 is a valid CAS Registry Number.

107793-07-7Relevant academic research and scientific papers

Contrasting Frustrated Lewis Pair Reactivity with Selenium- and Boron-Based Lewis Acids

Wilkins, Lewis C.,Günther, Benjamin A. R.,Walther, Melanie,Lawson, James R.,Wirth, Thomas,Melen, Rebecca L.

, p. 11292 - 11295 (2016)

The activation of π-bonds in diynyl esters has been investigated by using soft and hard Lewis acids. In the case of the soft selenium Lewis acid PhSeCl, sequential activation of the alkyne bonds leads initially to an isocoumarin (1 equiv PhSeCl) and then

Palladium cross-coupling reactions on solid support using a new silylated linker

Duboc, Romain,Savignac, Monique,Genêt, Jean-Pierre

, p. 512 - 515 (2002)

The synthesis and the use in palladium cross-coupling reactions of a new silylated stable resin were described. The products have been cleaved from the support using mild conditions and purified with a scavenger ionic resin. A small library of coupling pr

Gold(i)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex

Okamura, Toshitaka,Fujiki, Shogo,Iwabuchi, Yoshiharu,Kanoh, Naoki

, p. 8522 - 8526 (2019)

A benchtop-stable reagent for the catalytic Nicholas reaction was developed. By combining a propargyl dicobalt hexacarbonyl cluster with an ortho-alkynylbenzoate unit and a fluorous tag, introduction of a propargyl hexacarbonyl complex on various aromatic compounds having acid- or base-sensitive functional groups becomes possible by using a gold(i) catalyst. In addition, the presence of a fluorous tag facilitates convenient separation of the target products from byproducts.

Cyclopentadienones as intermediates for the synthesis of highly functionalized biaryls

Pearson, Anthony J.,Kim, Jin Bum

, p. 8525 - 8527 (2003)

A new approach to the synthesis of substituted biaryls, via Diels-Alder reaction between cyclopentadienones and arylacetylenes, is described.

Cross-Metathesis of Terminal Alkynes

Lhermet, Rudy,Fürstner, Alois

, p. 13188 - 13193 (2014)

Terminal acetylenes are amongst the most problematic substrates for alkyne metathesis because they tend to undergo rapid polymerization on contact with a metal alkylidyne. The molybdenum complex 3 endowed with triphenylsilanolate ligands, however, is capable of inducing surprisingly effective cross-metathesis reactions of terminal alkyl acetylenes with propynyl(trimethyl)silane to give products of type R1-C≡CSiMe. This unconventional way of introducing a silyl substituent onto an alkyne terminus complements the conventional tactics of deprotonation/silylation and excels as an orthogonal way of alkyne protecting group chemistry for substrates bearing base-sensitive functionalities. Moreover, it is shown that even terminal aryl acetylenes can be cross-metathesized with internal alkyne partners. These unprecedented transformations are compatible with various functional groups. The need to suppress acetylene formation, which seems to be a particularly effective catalyst poison, is also discussed.

Cys–Cys and Cys–Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Ceballos, Javier,Grinhagena, Elija,Sangouard, Gontran,Heinis, Christian,Waser, Jerome

, p. 9022 - 9031 (2021)

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein-protein interactions. Herein, we report bis-functional hypervalent iodine reagents for two-component cysteine-cysteine and cysteine-lysine stapling yielding structurally diverse thioalkyne linkers. This stapling method works with unprotected natural amino acid residues and does not require pre-functionalization or metal catalysis. The products are stable to purification and isolation. Post-stapling modification can be accessed via amidation of an activated ester, or via cycloaddition onto the formed thioalkyne group. Increased helicity and binding affinity to MDM2 was obtained for a i,i+7 stapled peptide.

Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate

Ming, Xiao-Xia,Wu, Shuai,Tian, Ze-Yu,Song, Jia-Wei,Zhang, Cheng-Pan

supporting information, p. 6795 - 6800 (2021/09/08)

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes. The vinylation proceeded smoothly at 25 °C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflate as a CH═CH2 transfer source in organic synthesis.

SMALL MOLECULE INHIBITORS OF A PROTEIN COMPLEX

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Paragraph 00153, (2020/12/29)

Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.

Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

Lin, Xinxin,Fang, Zheng,Zeng, Cuilian,Zhu, Chenlong,Pang, Xinyan,Liu, Chengkou,He, Wei,Duan, Jindian,Qin, Ning,Guo, Kai

supporting information, p. 13738 - 13742 (2020/10/02)

A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.

Tertiary amines acting as Alkyl radical equivalents enabled by a P/N heteroleptic Cu(I) photosensitizer

Zheng, Limeng,Jiang, Qinfang,Bao, Hanyang,Zhou, Bingwei,Luo, Shu-Ping,Jin, Hongwei,Wu, Huayue,Liu, Yunkui

supporting information, p. 8888 - 8893 (2020/11/30)

An unprecedented exploration of tertiary amines as alkyl radical equivalents for cross-coupling with aromatic alkynes to access allylarenes has been achieved by a P/N heteroleptic Cu(I)based photosensitizer under photoredox catalysis conditions. Mechanist

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